mafosfamide Report issue

Small molecule Experimental
AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

NOW
  • Now
Mafosfamide (INN) is an oxazaphosphorine (cyclophosphamide-like) alkylating agent under investigation as a chemotherapeutic. It is metabolized by cytochrome P450 into 4-hydroxycyclophosphamide, which is then converted into aldophosphamide, which, in turn yields the cytotoxic metabolites phosphoramide mustard and acrolein.   Wikipedia

Chemistry

  • SMILES: OS(=O)(=O)CCSC1CCOP(=O)(N1)N(CCCl)CCCl
  • InChIKey: PBUUPFTVAPUWDE-UHFFFAOYSA-N
  • Mol. Mass: 401.27
  • ALogP: 1.83
  • ChEMBL Molecule:
    mafosfamide  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No

Alternative names

2-((2-(bis(2-chloroethyl)amino)tetrahydro-2h-1,3,2-oxazaphosphorin-4-yl)thio)ethanesulfonic acid p-oxide | mafosfamide | z 7557 | z-7557

Organizations (10)

Research & Development (10)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (4)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (4)


 

Brain Neoplasms (Phase 1)

Leukemia (Phase 1)

Lymphoma (Phase 1)

Meningeal Neoplasms (Phase 1)

Overview

  • Highest Phase: Phase 1
  • # of Trials: 4
  • # of Trial Organizations: 10

Trials by Phase

Trial Phase Start Date Organizations Indications

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