Active Ingredient History

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The alkaloid L-(-)-scopolamine [L-(-)-hyoscine], a belladonna alkaloid, competitively inhibits muscarinic receptors for acetylcholine and acts as a nonselective muscarinic antagonist, producing both peripheral antimuscarinic properties and central sedative, antiemetic, and amnestic effects. Scopolamine acts: i) as a competitive inhibitor at postganglionic muscarinic receptor sites of the parasympathetic nervous system, and ii) on smooth muscles that respond to acetylcholine but lack cholinergic innervation. It has been suggested that scopolamine acts in the central nervous system (CNS) by blocking cholinergic transmission from the vestibular nuclei to higher centers in the CNS and from the reticular formation to the vomiting center. Scopolamine can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, cause drowsiness, dilate the pupils, increase heart rate, and depress motor function. Scopolamine is used for premedication in anesthesia and for the prevention of nausea and vomiting (post operative and associated with motion sickness).   NCATS

More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Topical
  • Pro Drug: No

Drug Pricing (per unit)

United States

$9.2350 - $17.9560
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

(1s,3s,5r,6r,7s)-6,7-epoxytropan-3-yl (2s)-3-hydroxy-2-phenylpropanoate | 6,7-epoxytropine tropate | 6-beta,7-beta-epoxy-3-alpha-tropanyl s-(-)-tropate | [7(s)-(1α,2β,4β,5α,7β)]-9-butyl-7-(3-hydroxy- 1-oxo-2-phenylpropoxy)-9-methyl-3-oxa- 9-azonitricyclo[3.3.1.0(2,4)]nonane | alpha-(hydroxymethyl)benzeneacetic acid 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(2.4))non-7-yl ester | buscopan | butylhyoscine | butylscopolamine | butylscopolaminebromide | butylscopolamine bromide | butylscopolammonium | hyoscine | (-)-hyoscine | hyoscine butylbromide | hyoscine butyl bromide | hyoscine hydrobromide | isopto hyoscine | isoptpo hyoscine | joy-rides | levo-duboisine | n-butylscopolammonium bromide | scopalamine | scopine (-)-tropate | scopine (−)-tropate | scopoderm | scopoderm tts | scopolamine | (-)-scopolamine | scopolamine bromobutylate | scopolamine butylbromide | scopolamine butyl hydroxide | scopolamine hcl | scopolamine hydrobromide | scopolamine hydrochloride | (-)-scopolamine,n-butyl-, bromide | scopolamine n-butylbromide | transcop | transderm | transderm-scop

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