Active Ingredient History
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 belongs to the family of interleukin-12. IL-12 family is unique in comprising the only heterodimeric cytokines, which includes IL-12, IL-23, IL-27 and IL-35. Despite sharing many structural features and molecular partners, they mediate surprisingly diverse functional effects. Wikipedia
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Acquired Immunodeficiency Syndrome (Phase 1)
Adrenocortical Carcinoma (Phase 1)
Alphapapillomavirus (Phase 1/Phase 2)
Anus Neoplasms (Phase 1/Phase 2)
Appendix (Phase 1)
Bile Duct Neoplasms (Phase 1)
Breast Neoplasms (Phase 2)
Breast Neoplasms, Male (Phase 1)
Carcinoma (Phase 1/Phase 2)
Carcinoma, Adenoid Cystic (Phase 1)
Carcinoma, Islet Cell (Phase 1)
Carcinoma, Mucoepidermoid (Phase 1)
Carcinoma, Non-Small-Cell Lung (Phase 1)
Carcinoma, Renal Cell (Phase 1)
Carcinoma, Squamous Cell (Phase 1)
Colonic Neoplasms (Phase 1/Phase 2)
Colorectal Neoplasms (Phase 2)
Colostomy (Phase 2)
Cryptosporidiosis (Phase 1/Phase 2)
Endometrial Neoplasms (Phase 1)
Esophageal Neoplasms (Phase 1)
Fallopian Tube Neoplasms (Phase 1)
Gallbladder Neoplasms (Phase 1)
Gastrinoma (Phase 1)
Gestational Trophoblastic Disease (Phase 1)
Glioblastoma (Phase 1/Phase 2)
Glioma (Phase 1/Phase 2)
Glucagonoma (Phase 1)
Hamartoma (Phase 2)
Head and Neck Neoplasms (Phase 1/Phase 2)
HIV Infections (Phase 1/Phase 2)
Hodgkin Disease (Phase 2)
Human papillomavirus 16 (Phase 1/Phase 2)
Immunologic Factors (Phase 1/Phase 2)
Inflammatory Breast Neoplasms (Phase 1)
Insulinoma (Phase 1)
Intestinal Neoplasms (Phase 1)
Kidney Neoplasms (Phase 1)
Leishmaniasis, Cutaneous (Phase 1)
Leukemia (Phase 1)
Leukemia, Lymphocytic, Chronic, B-Cell (Phase 2)
Leukemia, Myeloid, Acute (Phase 1)
Liver Neoplasms (Phase 1)
Lung Neoplasms (Phase 1)
Lymphoma (Phase 2)
Lymphoma, B-Cell, Marginal Zone (Phase 2)
Lymphoma, Follicular (Phase 2)
Lymphoma, Large B-Cell, Diffuse (Phase 2)
Lymphoma, Large-Cell, Immunoblastic (Phase 2)
Lymphoma, Mantle-Cell (Phase 2)
Lymphoma, Non-Hodgkin (Phase 2)
Lymphoma, T-Cell (Phase 2)
Melanoma (Phase 2)
Multiple Myeloma (Phase 2)
Mycobacterium Infections, Nontuberculous (Phase 1)
Mycosis Fungoides (Phase 2)
Myelodysplastic Syndromes (Phase 1)
Myeloproliferative Disorders (Phase 1)
Neoplasm Metastasis (Phase 1/Phase 2)
Neoplasms (Phase 2)
Neoplasms, Nerve Tissue (Phase 1/Phase 2)
Neoplasms, Neuroepithelial (Phase 1/Phase 2)
Neuroblastoma (Phase 1)
Neuroectodermal Tumors (Phase 1/Phase 2)
Oropharyngeal Neoplasms (Phase 1/Phase 2)
Ovarian Neoplasms (Phase 2)
Pancreatic Neoplasms (Phase 1)
Penile Neoplasms (Phase 1/Phase 2)
Pleural Effusion, Malignant (Phase 1)
Precancerous Conditions (Phase 1)
Prostatic Neoplasms (Phase 2)
Radiation Oncology (Phase 2)
Rectal Neoplasms (Phase 1)
Salivary Gland Neoplasms (Phase 1)
Sarcoma (Phase 2)
Sarcoma, Kaposi (Phase 1/Phase 2)
Sezary Syndrome (Phase 2)
Small Cell Lung Carcinoma (Phase 1)
Somatostatinoma (Phase 1)
Squamous Cell Carcinoma of Head and Neck (Phase 2)
Stomach Neoplasms (Phase 1)
Testicular Neoplasms (Phase 1)
Thyroid Carcinoma, Anaplastic (Phase 1)
Thyroid Neoplasms (Phase 1)
Urethral Neoplasms (Phase 1)
Urinary Bladder Neoplasms (Phase 1)
Uterine Cervical Neoplasms (Phase 2)
Vaccines (Phase 1/Phase 2)
Vaginal Neoplasms (Phase 1/Phase 2)
Vipoma (Phase 1)
Vulvar Neoplasms (Phase 1/Phase 2)
Waldenstrom Macroglobulinemia (Phase 2)
Trial | Phase | Start Date | Organizations | Indications |
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