Active Ingredient History
Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2 (IL-2). Like IL-2, IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain (CD122) and the common gamma chain. IL-15 is secreted by mononuclear phagocytes following infection by virus(es). This cytokine induces the proliferation of natural killer cells, i.e. cells of the innate immune system whose principal role is to kill virally infected cells. Wikipedia
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
B-Lymphocytes (Phase 1)
Brain Neoplasms (Phase 1)
Bronchiectasis (Phase 1)
Carcinoma (Phase 1)
Carcinoma, Non-Small-Cell Lung (Phase 1)
Carcinoma, Renal Cell (Phase 2)
HIV Infections (Phase 1)
Leukemia (Phase 1)
Leukemia, Lymphocytic, Chronic, B-Cell (Phase 1)
Leukemia-Lymphoma, Adult T-Cell (Phase 1)
Leukemia, Myeloid, Acute (Phase 2)
Leukemia, Prolymphocytic, T-Cell (Phase 1)
Lymphoma (Phase 1)
Lymphoma, Large-Cell, Anaplastic (Phase 1)
Lymphoma, T-Cell (Phase 1)
Melanoma (Phase 1/Phase 2)
Mycosis Fungoides (Phase 1)
Myelodysplastic Syndromes (Phase 1)
Neoplasms (Phase 1)
Neuroblastoma (Phase 1)
Sarcoma (Phase 1)
Sezary Syndrome (Phase 1)
Skin Neoplasms (Phase 1/Phase 2)
Squamous Cell Carcinoma of Head and Neck (Phase 1)
| Trial | Phase | Start Date | Organizations | Indications |
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