propylthiouracil Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

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Propylthiouracil is thyroid peroxidase inhibitor used to treat hyperthyroidism, which includes hyperthyroidism due to Graves' disease and toxic multinodular goiter. Propylthiouracil is used to ameliorate symptoms of hyperthyroidism in preparation for thyroidectomy or radioactive iodine therapy in patients who are intolerant of methimazole.   NCATS

Chemistry

  • SMILES: CCCC1=CC(=O)NC(=S)N1
  • InChIKey: KNAHARQHSZJURB-UHFFFAOYSA-N
  • Mol. Mass: 170.232
  • ALogP: 1.38
  • ChEMBL Molecule:
    propylthiouracil  
More Chemistry

Pharmacology

Drug Pricing (per unit)

United States

$0.0339 - $0.5569

Australia

$0.1220
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Alternative names

2,3-dihydro-6-propyl-2-thioxo-4(1h)-pyrimidinone | 2-mercapto-6-propyl-4-pyrimidone | 2-mercapto-6-propylpyrimid-4-one | 2-thio-4-oxo-6-propyl-1,3-pyrimidine | 2-thio-6-propyl-1,3-pyrimidin-4-one | 4-propyl-2-thiouracil | 6-n-propylthiouracil | 6-propyl-2-thio-2,4(1h,3h)pyrimidinedione | 6-propyl-2-thioxo-2,3-dihydropyrimidin-4(1h)-one | 6-propylthiouracil | 6-thio-4-propyluracil | procasil | propacil | propiltiouracilo | propylthiouracil | propylthiouracile | propylthiouracilum | prothiurone | prothyran | thyreostat | thyreostat ii

Organizations (25)

Research & Development (8)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (17)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (8)

Approved Indications (1)


 

Hyperthyroidism (approved 1947)

Experimental Indications - Clinical Trial Phases 1-4 (8)


 

Atherosclerosis (Phase 3)

Drug Interactions (Phase 1)

Graves Disease (Phase 3)

Graves Ophthalmopathy (Phase 4)

Hyperthyroidism (Phase 3)

Ischemic Stroke (Phase 2)

Pediatrics (Phase 3)

Physiology (Phase 3)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 6
  • # of Trial Organizations: 8

Trials by Phase

Trial Phase Start Date Organizations Indications

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