Calcium salicylate is the calcium salt of salicylic acid. The anti-cancer effectiveness of calcium salicylate has been investigated on human HT-1080 fibrosarcoma cell lines. Low calcium salicylate concentrations did not retard tumor growth progression significantly but its cytotoxic characteristics were proven to be prominent by various morphological and immunocytological techniques - approximately 25% apoptosis after treatment with calcium salicylate. This compound up-regulated the expression of p53, p21 and Bax, and down-regulated Bcl-2 in HT-1080 cells. In addition, calcium salicylate is used in root canal filling material development. NCATS
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