Active Ingredient History
Thiamine, also known as vitamin B1, plays a key role in the human metabolism. It is present in many dietary sources such as meats, eggs, fish, beans and peas, nuts, and whole grains. Upon administration thiamine is converted by thiamine pyrophosphokinase-1 (TPK1) to the active form, thiamine pyrophosphate, which serves as a cofactor for enzymes involved in the TCA cycle and the non-oxidative part of the pentose phosphate pathway. The lack of thiamine may cause the thiamine deficiency. The classical syndrome caused primarily by thiamine deficiency in humans is beriberi, however, symptoms of thiamine deficiency also include congestive heart failure, metabolic acidosis, confusion, ataxia and seizures. Thiamine is a component of many vitamin complexes, which are approved for the treatmen and prevention of general vitamin deficiency, including the thiamine deficiency. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Thiamine Deficiency (approved 1953)
Acidosis, Lactic (Phase 4)
Acquired Immunodeficiency Syndrome (Phase 4)
Acute Lung Injury (Phase 2/Phase 3)
Aging (Phase 1/Phase 2)
Alcoholism (Phase 4)
Alcohol Withdrawal Delirium (Phase 2/Phase 3)
Alzheimer Disease (Phase 2)
Amyotrophic Lateral Sclerosis (Phase 1)
Anemia (Phase 4)
Anemia, Pernicious (Phase 4)
Beriberi (Phase 1)
Blood (Phase 4)
Body Fluids (Phase 4)
Brain Injuries (Phase 2)
Cardiac Surgical Procedures (Phase 2)
Cardiopulmonary Bypass (Phase 4)
Child (Phase 4)
Coronary Artery Bypass (Phase 2)
COVID-19 (Phase 4)
Critical Illness (Phase 4)
Deficiency Diseases (Phase 4)
Delirium (Phase 2)
Diabetes Mellitus (Phase 2)
Diabetes Mellitus, Type 1 (Phase 1/Phase 2)
Diabetes Mellitus, Type 2 (Phase 4)
Diabetic Ketoacidosis (Phase 2)
Diabetic Nephropathies (Phase 4)
Diabetic Neuropathies (Phase 3)
Endothelial Cells (Phase 4)
Essential Hypertension (Phase 4)
Fatigue (Phase 4)
Hair (Phase 4)
Healthy Volunteers (Phase 3)
Heart Arrest (Phase 2)
Heart Defects, Congenital (Phase 4)
Heart Diseases (Phase 3)
Heart Failure (Phase 4)
Heart Failure, Systolic (Phase 1)
Hematopoietic Stem Cell Transplantation (Phase 2)
Hepatitis B, Chronic (Phase 4)
HIV (Phase 2)
HIV Infections (Phase 4)
Huntington Disease (Phase 2)
Hyperemesis Gravidarum (Phase 3)
Hypertension (Phase 4)
Hyperthermia (Phase 1)
Kidney Diseases (Phase 2)
Korsakoff Syndrome (Phase 4)
Lipodystrophy (Phase 4)
Liver Cirrhosis, Biliary (Phase 4)
Magnesium Deficiency (Phase 2/Phase 3)
Metabolic Diseases (Phase 2/Phase 3)
Metabolism (Phase 1)
Migraine Disorders (Phase 1/Phase 2)
Migraine with Aura (Phase 1/Phase 2)
Neoplasms (Phase 3)
Neoplastic Stem Cells (Phase 2)
Obesity (Phase 4)
Out-of-Hospital Cardiac Arrest (Phase 2)
Post-Acute COVID-19 Syndrome (Phase 4)
Post-Cardiac Arrest Syndrome (Phase 2)
Pregnancy Complications (Phase 4)
Quality of Life (Phase 2)
Respiratory Distress Syndrome (Phase 2/Phase 3)
Respiratory Insufficiency (Phase 2)
Sepsis (Phase 4)
Shock (Phase 2)
Shock, Septic (Phase 4)
Sports Medicine (Phase 1)
Steatitis (Phase 4)
Stroke (Phase 1)
Subarachnoid Hemorrhage (Phase 3)
Thiamine (Phase 2)
Thiamine Deficiency (Phase 4)
Thoracic Surgery (Phase 4)
Tryptophan (Phase 2)
Ureteral Diseases (Early Phase 1)
Vasoplegia (Phase 2)
Vertigo (Phase 4)
Wernicke Encephalopathy (Phase 2/Phase 3)
Wounds and Injuries (Phase 3)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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