API | piromelatine

piromelatine Report issue

Small molecule Experimental

AACT DrugBank MeSH PubChem

Active Ingredient History

NOW

Piromelatine (Neu-P11) is a multimodal sleep drug under development by Neurim Pharmaceuticals. It is an agonist at melatonin MT1/MT2 and serotonin 5-HT1A/5-HT1D receptors. Neurim is conducting a phase II randomized, placebo controlled trial of cognitive and sleep effects in Alzheimer's disease. ^Wikipedia

Chemistry

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More Chemistry

Pharmacology

Mechanism of Action:
- Melatonin receptor type 1A (Homo sapiens) ^UniProt
- Melatonin receptor type 1B (Homo sapiens) ^UniProt
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n-(2-(5-methoxy-indol-3-yl)-ethyl)-4-oxo-4h-pyran-2-carboxamide | neu-p11 | piromelatine

Organizations (4)

Research & Development (4)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (0)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (2)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (2)

Alzheimer Disease (Phase 2/Phase 3)

Sleep Initiation and Maintenance Disorders (Phase 2)

Overview

Highest Phase: Phase 3
# of Trials: 4
# of Trial Organizations: 4

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

Feedback

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