sodium picosulfate (Preopik) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central MeSH PubChem

Active Ingredient History

NOW
  • Now
Picosulfuric acid (as sodium picosulfate) is a contact laxative, which is used in combination with: magnesium oxide, and anhydrous citric acid for cleansing of the colon as a preparation for colonoscopy in adults. Sodium picosulfate is a prodrug. It has no significant direct physiological effect on the intestine. But it is hydrolyzed by colonic bacteria to form an active metabolite: bis-(p-hydroxy-phenyl)-pyridyl-2-methane, BHPM, which acts directly on the colonic mucosa to stimulate colonic peristalsis   NCATS

Chemistry

  • SMILES: OS(=O)(=O)Oc1ccc(cc1)C(c2ccc(OS(=O)(=O)O)cc2)c3ccccn3
  • InChIKey: UJIDKYTZIQTXPM-UHFFFAOYSA-N
  • Mol. Mass: 437.45
  • ALogP: 2.63
  • ChEMBL Molecules:
    picosulfuric acid  
    sodium picosulfate  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Combination drugs

( magnesium oxide, sodium picosulfate (Preopik), citric acid - other name: clenpiq )

Alternative names

4,4'-(2-picolylidene)bisphenylsulfuric acid | 4,4'-(picoliliden)-bis-phenylsulphate | citrafleet | da-1773 | dulcolax pico | fe 999169 | la-391 | laxoberal | natrium picosulfate | otc concepts | pe | picolax | picoprep | picosalax | pico-salax | picosulfate | picosulfate sodium | picosulfol | picosulfuric acid | picosulphate | prepopik | rapilax | sodium picosulfate | sodium picosulfate, magnesium oxide and citric acid | sodium picosulphate

Organizations (65)

Research & Development (62)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (4)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (23)

Approved Indications (1)


 

Colonoscopy (approved 2012)

Experimental Indications - Clinical Trial Phases 1-4 (23)


 

Cathartics (Phase 4)

Colitis, Ulcerative (Phase 4)

Colon (Phase 4)

Colonic Diseases (Phase 4)

Colonic Neoplasms (Phase 3)

Colonic Polyps (Phase 3)

Colonoscopy (Phase 4)

Colorectal Neoplasms (Phase 4)

Constipation (Phase 3)

Drug-Related Side Effects and Adverse Reactions (Phase 3)

Drugs, Investigational (Phase 3)

Endoscopy (Phase 4)

General Surgery (Phase 4)

Glycemic Control (Phase 2)

Healthy Volunteers (Phase 2)

Inflammatory Bowel Diseases (Phase 3)

Intestinal Diseases (Phase 3)

Intestinal Neoplasms (Phase 4)

Intestine, Large (Phase 4)

Magnesium Sulfate (Phase 3)

Only Child (Phase 3)

Treatment Outcome (Phase 3)

Wounds and Injuries (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 61
  • # of Trial Organizations: 62

Trials by Phase

Trial Phase Start Date Organizations Indications

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