Active Ingredient History

  • Now
Penciclovir (DENAVIR®) is a synthetic acyclic guanine derivative with antiviral activity, mainly used to treat infections from herpes simplex virus (HSV) types 1 and 2. In cells infected with HSV-1 or HSV-2, the viral thymidine kinase phosphorylates penciclovir to a monophosphate form that, in turn, is converted by cellular kinases to the active form penciclovir triphosphate. Biochemical studies demonstrate that penciclovir triphosphate inhibits HSV polymerase competitively with deoxyguanosine triphosphate. Consequently, herpes viral DNA synthesis and, therefore, replication are selectively inhibited. Famciclovir (FAMVIR®) is a prodrug form of penciclovir with improved oral bioavailability.   NCATS

  • SMILES: Nc1nc(O)c2ncn(CCC(CO)CO)c2n1
  • Mol. Mass: 253.26
  • ALogP: -0.9
  • ChEMBL Molecules:
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Drug Pricing (per unit)

United States

$92.3680 - $156.2449
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

9-[2-hydroxy-1-(hydroxymethyl)-ethoxymethyl]guanine | 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine | 9-(4-hydroxy-3-hydroxymethylbut-1-yl)-guanine | 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]guanine | 9-(4-hydroxy-3-(hydroxymethyl)butyl)guanine | brl 39123 | brl-39123 | denavir | fenistil | novartis brand of penciclovir | pcv | pe2 | penciclovir | penciclovir, monosodium salt | penciclovir, monosodium salt, monohydrate | penciclovir sodium | penciclovirum | penciclovir visfarm | sb-ch brand of penciclovir | vectavir | visfarm brand of penciclovir


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