afatinib (gilotrif) Report issue

Small molecule Orphan Drug FDA Approved FDA Fast Track FDA Priority Review FDA
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Chemistry

Mol. Mass

485.95

ALogP

4.39

Rule of 5

Yes

Rule of 3

No
Details
  • SMILES: CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]4CCOC4
  • InChIKey: ULXXDDBFHOBEHA-CWDCEQMOSA-N
    InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
  • Chirality: Single Stereoisomer
  • Inorganic: No
  • Polymer: No

Sources

CHEMBL1173655   ChEMBL
afatinib *

CHEMBL2105712   ChEMBL
afatinib dimaleate

41UD74L59M   NCATS
afatinib *

Afatinib   Wikipedia

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