API | birabresib

birabresib Report issue

Small molecule Experimental

AACT ChEMBL PubChem

Active Ingredient History

NOW

Birabresib is an experimental small molecule inhibitor of BRD2, BRD3, and BRD4 under investigation for the treatment of cancer. It is in development by Merck & Co. It is currently in clinical trials for leukemia and glioblastoma. ^Wikipedia

Chemistry

SMILES: Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)Nc1ccc(O)cc1)c1nnc(C)n1-2
InChIKey: GNMUEVRJHCWKTO-FQEVSTJZSA-N
Mol. Mass: 492.0
ALogP: 5.53 Partition coefficient
ChEMBL Molecule:
birabresib

More Chemistry

Pharmacology

Mechanisms of Action:
- Bromodomain-containing protein 4 (Homo sapiens) ^UniProt
- Histone deacetylase 1 (Homo sapiens) ^UniProt
- Bromodomain-containing protein 2 (Homo sapiens) ^UniProt
- Bromodomain-containing protein 3 (Homo sapiens) ^UniProt
Multi-specific: Missing data
Black Box: No
Availability: Missing data
Delivery Methods: Missing data
Pro Drug: No

birabresib | mk-8628 | otx015 | otx-015

Organizations (2)

Research & Development (2)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (0)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (12)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (12)

Breast Neoplasms (Phase 1)

Carcinoma (Phase 1)

Carcinoma, Non-Small-Cell Lung (Phase 1)

Glioblastoma (Phase 1/Phase 2)

Leukemia, Myeloid, Acute (Phase 1/Phase 2)

Lymphoma, Large B-Cell, Diffuse (Phase 1)

Lymphoma, Large-Cell, Immunoblastic (Phase 1)

Multiple Myeloma (Phase 1)

Pancreatic Neoplasms (Phase 1)

Precursor Cell Lymphoblastic Leukemia-Lymphoma (Phase 1)

Prostatic Neoplasms, Castration-Resistant (Phase 1)

Triple Negative Breast Neoplasms (Phase 1)

Overview

Highest Phase: Phase 2
# of Trials: 6
# of Trial Organizations: 2

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

Feedback

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