permethrin (nix) Report issue

Small molecule Approved FDA Priority Review FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Permethrin is a synthetic pyrethrin derivative acts as a neurotoxin by depolarizing the nerve cell membrane. Permethrin disrupts the sodium channel current by which membrane repolarization is regulated resulting in fatal paralysis of the nerves in the exoskeletal respiratory muscles of susceptible arthropods, including lice and mite. Permethrin is sold under brand names NIx and Elimite to treat pediculosis, scabies and demodicidosis.   NCATS

Chemistry

  • SMILES: CC1(C)C(C=C(Cl)Cl)C1C(=O)OCC2=CC(OC3=CC=CC=C3)=CC=C2
  • InChIKey: RLLPVAHGXHCWKJ-UHFFFAOYSA-N
  • Mol. Mass: 391.288
  • ALogP: 6.11
  • ChEMBL Molecule:
    permethrin  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Over the Counter
  • Delivery Methods: Topical
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.1252 - $9.5910

Australia

$5.6674
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Alternative names

3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylic acid, (3-phenoxyphenyl) methyl ester | (3-phenoxyphenyl)methyl (+-)-cis,trans-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate | elimite | lyclear | lythrin | nedax | nix | permethrin | permetrin

Organizations (64)

Research & Development (57)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (9)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (9)

Approved Indications (2)


 

Lice Infestations (approved 1986)

Scabies (approved 1986)

Experimental Indications - Clinical Trial Phases 1-4 (9)


 

Impetigo (Phase 4)

Inflammation (Phase 4)

Lice Infestations (Phase 3)

Malaria (Phase 4)

Parasitic Diseases (Phase 4)

Pediculus (Phase 3)

Scabies (Phase 4)

Trachoma (Phase 2)

Yaws (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 40
  • # of Trial Organizations: 57

Trials by Phase

Trial Phase Start Date Organizations Indications

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