Active Ingredient History
Brexpiprazole is a novel D2 dopamine and serotonin 1A partial agonist, called serotonin-dopamine activity modulator (SDAM), and a potent antagonist of serotonin 2A receptors, noradrenergic alpha 1B and 2C receptors. Brexpiprazole is approved for the treatment of schizophrenia, and as an adjunctive treatment for major depressive disorder (MDD). Although it failed Phase II clinical trials for ADHD, it has been designed to provide improved efficacy and tolerability (e.g., less akathisia, restlessness and/or insomnia) over established adjunctive treatments for major depressive disorder (MDD).Brexpiprazole is sold under the brand name Rexulti. Although the mechanism of action of brexpiprazole in the treatment of MDD and schizophrenia is unclear, the efficacy of brexpiprazole may be attributed to partial agonist activity at serotonin 1A and dopamine D2 receptors, and antagonist activity at serotonin 2A receptors. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Alcoholism (Phase 2)
Alzheimer Disease (Phase 3)
Anxiety (Phase 3)
Autism Spectrum Disorder (Phase 3)
Autistic Disorder (Phase 1)
Bipolar Disorder (Phase 4)
Borderline Personality Disorder (Phase 2/Phase 3)
Conduct Disorder (Phase 1)
Depression (Phase 4)
Depressive Disorder (Phase 3)
Depressive Disorder, Major (Phase 4)
Health (Phase 1)
Healthy Volunteers (Phase 1)
Irritable Mood (Phase 3)
Mania (Phase 3)
Mental Disorders (Phase 3)
Mood Disorders (Phase 3)
Nervous System Diseases (Phase 3)
Sleep Disorders, Intrinsic (Phase 3)
Stress Disorders, Post-Traumatic (Phase 3)
Substance-Related Disorders (Phase 4)
Trial | Phase | Start Date | Organizations | Indications |
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