Active Ingredient History

NOW
  • Now
The potential antiviral effect of adefovir, an acyclic nucleoside phosphonate analog of 2′-deoxyadenosine monophosphate, was first studied by Holý and De Clercq in 1980s. Adefovir is an acyclic nucleotide analog of adenosine monophosphate which is phosphorylated to the active metabolite adefovir diphosphate by cellular kinases. Adefovir diphosphate inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate deoxyadenosine triphosphate and by causing DNA chain termination after its incorporation into viral DNA. Oral adefovir dipivoxil is effective and generally well tolerated in HBeAg-positive and -negative patients chronically infected with wild-type or lamivudine-resistant HBV.   NCATS

  • SMILES: NC1=NC=NC2=C1N=CN2CCOCP(O)(O)=O
  • InChIKey: SUPKOOSCJHTBAH-UHFFFAOYSA-N
  • Mol. Mass: 273.1857
  • ALogP: -0.44
  • ChEMBL Molecules:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Missing data
  • Pro Drug: No

Drug Pricing (per unit)

Australia

$11.0671

United States

$15.3357 - $31.6210
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

9-(2-((-bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine | 9-(2-phosphonomethoxyethyl)adenine | 9-(2-phosphonylmethoxyethyl)adenine | 9-pmea | adefovir | adefovir depivoxil | adefovir di(pivaloyloxymethyl) ester | adefovir dipivoxil | adefovir pivoxil | bis-pom pmea | gs-0393 | gs-0840 | gs 840 | hepsera | preveon

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