Active Ingredient History

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Trodusquemine is an aminosterol similar to squalamine that is an allosteric inhibitor of protein-tyrosine phosphatase 1B (PTP1B). It was isolated from the dogfish shark by scientists at Magainin Pharmaceuticals in 2000 and underwent some drug development as a potential treatment for diabetes or obesity, but the company ran out of money and closed in 2009.   Wikipedia

  • SMILES: CC(C)[C@@H](CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@H]4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)NCCCNCCCCNCCCN)OS(=O)(=O)O
  • InChIKey: WUJVPODXELZABP-FWJXURDUSA-N
  • Mol. Mass: 685.07
  • ALogP: 5.53
  • ChEMBL Molecule:
More Chemistry
3beta-n-1(spermine)-7alpha, 24r-dihydroxy-5alpha-cholestane 24-sulfate | 3-n-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate | msi1436 | msi 1436 | msi-1436 | msi-1436c | trodusquemine

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