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nedisertib Report issue

Small molecule Experimental

AACT

Active Ingredient History

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Chemistry

SMILES: COc1ccc([C@@H](O)c2cc(-c3ncnc4cc(N5CCOCC5)ccc34)c(F)cc2Cl)nn1
InChIKey: MOWXJLUYGFNTAL-DEOSSOPVSA-N
Mol. Mass: 481.92
ALogP: 3.81 Partition coefficient
ChEMBL Molecule:
nedisertib

More Chemistry

Pharmacology

Mechanism of Action:
- DNA-dependent protein kinase catalytic subunit (Homo sapiens) ^UniProt
Multi-specific: Missing data
Black Box: No
Availability: Missing data
Delivery Methods: Missing data
Pro Drug: No

msc2490484a

Organizations (7)

Research & Development (7)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (0)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (16)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (16)

Carcinoma, Ovarian Epithelial (Phase 1)

Cholangiocarcinoma (Phase 1/Phase 2)

Endometrial Neoplasms (Phase 1)

Fallopian Tube Neoplasms (Phase 1)

Gallbladder Neoplasms (Phase 1/Phase 2)

Glioblastoma (Phase 1)

Gliosarcoma (Phase 1)

Hamartoma (Phase 1)

Leukemia, Lymphocytic, Chronic, B-Cell (Phase 1)

Leukemia, Myeloid, Acute (Phase 1)

Neoplasm Metastasis (Phase 1/Phase 2)

Neoplasms (Phase 1/Phase 2)

Ovarian Neoplasms (Phase 1)

Pancreatic Neoplasms (Phase 1/Phase 2)

Prostatic Neoplasms (Phase 1/Phase 2)

Prostatic Neoplasms, Castration-Resistant (Phase 1/Phase 2)

Overview

Highest Phase: Phase 2
# of Trials: 9
# of Trial Organizations: 7

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

Feedback

Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

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