tepotinib (Tepmetko) Report issue

Small molecule Orphan Drug FDA Approved FDA Accelerated Approval FDA Priority Review FDA
AACT ChEMBL PubChem

Active Ingredient History

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c-Met inhibitors are a class of small molecules that inhibit the enzymatic activity of the c-Met tyrosine kinase, the receptor of hepatocyte growth factor/scatter factor (HGF/SF). These inhibitors may have therapeutic application in the treatment of various types of cancers.   Wikipedia

Chemistry

  • SMILES: CN1CCC(COc2cnc(nc2)c3cccc(CN4N=C(C=CC4=O)c5cccc(c5)C#N)c3)CC1
  • InChIKey: AHYMHWXQRWRBKT-UHFFFAOYSA-N
  • Mol. Mass: 492.58
  • ALogP: 4.01
  • ChEMBL Molecule:
    tepotinib  
More Chemistry

Pharmacology

Alternative names

emd-1214063 | msc-2156119 | msc2156119j | msc-2156119j | tepotinib

Organizations (13)

Research & Development (13)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (12)

Approved Indications (1)


 

Carcinoma, Non-Small-Cell Lung (approved 2021)

Experimental Indications - Clinical Trial Phases 1-4 (12)


 

Brain Neoplasms (Phase 1)

Carcinoma, Hepatocellular (Phase 1/Phase 2)

Carcinoma, Non-Small-Cell Lung (Phase 2)

Colorectal Neoplasms (Phase 2)

Esophageal Neoplasms (Phase 1/Phase 2)

Healthy Volunteers (Phase 1)

Liver Diseases (Phase 1)

Lung Neoplasms (Phase 2)

Mutation (Phase 2)

Neoplasms (Phase 2)

Proto-Oncogene Proteins c-met (Phase 2)

Stomach Neoplasms (Phase 1/Phase 2)

Overview

  • Highest Phase: Phase 2
  • # of Trials: 25
  • # of Trial Organizations: 13

Trials by Phase

Trial Phase Start Date Organizations Indications

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