metaraminol (aramine) Report issue

Small molecule Approved FDA Priority Review FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem

Active Ingredient History

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Metaraminol is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure, is an adrenergic receptor alpha-1 agonist.. Metaraminol is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complications, and shock associated with brain damage due to trauma or tumor. Metaraminol is also used in the treatment of priapism, in spite of this application was not approved, it appears to be effective.   NCATS

Chemistry

More Chemistry

Pharmacology

Alternative names

1-metaraminol | 1-(m-hydroxyphenyl)-2-amino-1-propanol | 2-amino-1-(m-hydroxyphenyl)-1-propanol | 3-hydroxyphenylisopropanolamine | alpha-(1-aminoethyl)-3-hydroxybenzenemethanol | alpha-(m-hydroxyphenyl)-beta-aminopropanol | aramine | (-)-erythro-metaraminol | hydroxynorephedrine | hydroxyphenylpropanolamine | l-metaraminol | metaradrine | metaradrine bitartrate | metaraminol | (-)-metaraminol | métaraminol | metaraminol bitartrate | metaraminolum | (-)-m-hydroxynorephedrine | m-hydroxynorephedrine | m-hydroxy norephedrine | m-hydroxyphenylpropanolamine | m-hydroxypropadrine

Organizations (10)

Research & Development (4)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (6)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (6)

Approved Indications (2)


 

Hemorrhage

Shock

Experimental Indications - Clinical Trial Phases 1-4 (4)


 

Cesarean Section (Phase 4)

Hypotension (Phase 2)

Pre-Eclampsia (Phase 3)

Priapism ()

Overview

  • Highest Phase: Phase 4
  • # of Trials: 5
  • # of Trial Organizations: 4

Trials by Phase

Trial Phase Start Date Organizations Indications

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