Active Ingredient History
Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities. Used for the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Vitamin B Deficiency (approved 1972)
Acidosis, Lactic (Phase 2/Phase 3)
Acute Pain (Phase 3)
Alcohol-Induced Disorders (Phase 2)
Alcoholism (Phase 4)
Alcohol Withdrawal Delirium (Phase 2/Phase 3)
Alzheimer Disease (Phase 3)
Anemia (Phase 4)
Anemia, Pernicious (Phase 4)
Anesthesia and Analgesia (Early Phase 1)
Anxiety Disorders (Phase 3)
Asthma (Phase 2)
Atherosclerosis (Phase 2/Phase 3)
Attention Deficit Disorder with Hyperactivity (Phase 2/Phase 3)
Autism Spectrum Disorder (Phase 2)
Biological Availability (Phase 1)
Bipolar Disorder (Phase 2)
Brain Injuries, Traumatic (Phase 2)
Breast Neoplasms (Phase 3)
Carcinoma, Hepatocellular (Phase 2/Phase 3)
Cardiovascular Diseases (Phase 4)
Cerebral Infarction (Phase 3)
Colorectal Neoplasms (Phase 3)
Coronary Artery Disease (Phase 3)
Coronary Disease (Phase 2)
Coronavirus Infections (Phase 3)
COVID-19 (Phase 3)
Deficiency Diseases (Phase 2/Phase 3)
Dementia (Phase 3)
Depression (Phase 3)
Dermatology (Phase 3)
Diabetes Mellitus (Phase 4)
Diabetes Mellitus, Type 2 (Phase 2)
Diabetic Retinopathy (Phase 4)
Drugs, Investigational (Phase 3)
Endometrial Neoplasms (Phase 3)
Endothelial Cells (Phase 2)
Epidermal Cells (Phase 2)
Epilepsy (Phase 4)
Fallopian Tube Neoplasms (Phase 3)
Fragile X Syndrome (Phase 2)
General Surgery (Phase 3)
Hamartoma (Phase 3)
Hand-Foot Syndrome (Phase 3)
Healthy Volunteers (Phase 1)
Heart Diseases (Phase 2)
Heart Rate (Phase 1)
Hepatitis, Alcoholic (Phase 4)
Hepatitis B, Chronic (Phase 4)
HIV (Phase 2)
HIV Infections (Phase 4)
Hot Flashes (Phase 2)
Hyperemesis Gravidarum (Phase 3)
Hyperhomocysteinemia (Phase 3)
Hyperoxaluria (Phase 2)
Hypertension (Phase 2)
Inflammation (Phase 1)
Inositol (Phase 3)
Irritable Bowel Syndrome (Phase 3)
Labor, Obstetric (Phase 3)
Leiomyoma (Phase 3)
Leukemia, Plasma Cell (Phase 2)
Liver Diseases, Alcoholic (Phase 2)
Lymphoma (Phase 2)
Lymphoma, Large-Cell, Immunoblastic (Phase 2/Phase 3)
Magnesium Deficiency (Phase 2/Phase 3)
Malnutrition (Early Phase 1)
Metabolic Syndrome (Phase 2)
Morning Sickness (Phase 4)
Multiple Myeloma (Phase 2)
Mycobacterium tuberculosis (Phase 3)
Myocardial Infarction (Phase 4)
Myocardial Ischemia (Phase 3)
Myocardial Revascularization (Phase 2)
Neoplasms (Phase 4)
Nerve Degeneration (Phase 2)
Nodding Syndrome (Phase 2)
Non-alcoholic Fatty Liver Disease (Phase 4)
Obesity (Phase 4)
Ovarian Neoplasms (Phase 3)
Oxidative Stress (Phase 2/Phase 3)
Palmar Plate (Phase 3)
Pharmacology (Phase 2/Phase 3)
Plasmacytoma (Phase 2)
Prediabetic State (Phase 4)
Pregnancy (Phase 3)
Pregnancy Complications (Phase 4)
Problem Behavior (Phase 4)
Prostatic Neoplasms (Phase 2)
Psychological Distress (Phase 2)
Psychophysiologic Disorders (Phase 3)
Pyridoxine (Phase 4)
Quality of Life (Phase 3)
Reperfusion Injury (Phase 3)
Schizophrenia (Phase 4)
Sepsis (Phase 3)
Shock, Septic (Phase 3)
Spasms, Infantile (Phase 3)
Steatitis (Phase 4)
ST Elevation Myocardial Infarction (Phase 4)
Stomach Neoplasms (Early Phase 1)
Stroke (Phase 4)
Tardive Dyskinesia (Phase 3)
Tuberculosis (Phase 4)
Tuberculosis, Multidrug-Resistant (Phase 3)
Tuberculosis, Pulmonary (Phase 2)
Vertigo (Phase 4)
Vitamin B 6 (Phase 3)
Vitamin D (Phase 3)
Wernicke Encephalopathy (Phase 2/Phase 3)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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