masoprocol (actinex) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Misoprostol is an antineoplastic drug used to treat skin growths caused by sun exposure. Masoprocol is a novel antineoplastic agent was used for the treatment of actinic keratoses (precancerous skin growths that can become malignant if left untreated). Masoprocol was withdrawn from the U.S. market in June 1996. It is not known exactly how Masoprocol works. Studies have shown that masoprocol is a potent 5-lipoxygenase inhibitor and has antiproliferative activity against keratinocytes in tissue culture, but the relationship between this activity and its effectiveness in actinic keratoses is unknown. Masoprocol also inhibits prostaglandins but the significance of this action is not yet known. Symptoms of overdose or allergic reaction include bluish coloration of skin, dizziness, severe, or feeling faint, wheezing or trouble in breathing.   NCATS

Chemistry

More Chemistry

Pharmacology

Alternative names

actinex | chx-100 | erythro-nordihydroguaiaretic acid | insm-18 | masoprocol | masoprocolum | meso-1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane | meso-2,3-bis(3,4-dihydroxyphenylmethyl)butane | meso-4,4'-(2,3-dimethyl-1,4-butanediyl)bis(pyrocatechol) | meso-4,4'-(2,3-dimethyltetramethylene)dipyrocatechol | meso-4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol | meso-ndga | meso-nordihydroguaiaretic acid | mesonordihydroguaiaretic acid | meso-β,γ-dimethyl-α,δ-bis(3,4-dihydroxyphenyl)butan | nordihydroguaiaretic acid

Organizations (4)

Research & Development (3)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (2)

Approved Indications (1)


 

Keratosis, Actinic (approved 1992)

Experimental Indications - Clinical Trial Phases 1-4 (1)


 

Prostatic Neoplasms (Phase 2)

Overview

  • Highest Phase: Phase 2
  • # of Trials: 2
  • # of Trial Organizations: 3

Trials by Phase

Trial Phase Start Date Organizations Indications

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