malic acid Report issue

Small molecule Experimental
AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

NOW
  • Now
Malic acid is an organic compound with the molecular formula HO2CCH(OH)CH2CO2H. It is a dicarboxylic acid that is made by all living organisms, contributes to the sour taste of fruits, and is used as a food additive. Malic acid has two stereoisomeric forms, though only the L-isomer exists naturally. The salts and esters of malic acid are known as malates. The malate anion is a metabolic intermediate in the citric acid cycle.   Wikipedia

Chemistry

  • SMILES: OC(CC(=O)O)C(=O)O
  • InChIKey: BJEPYKJPYRNKOW-UHFFFAOYSA-N
  • Mol. Mass: 134.09
  • ALogP: -1.09
  • ChEMBL Molecule:
    malic acid  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No

Alternative names

calcium (hydroxy-1-malate) hexahydrate | e296 | malate | malic acid | malic acid, calcium salt, (1:1), (s)-isomer | malic acid, disodium salt | malic acid, disodium salt, (r)-isomer | malic acid, disodium salt, (s)-isomer | malic acid, magnesium salt (2:1) | malic acid, monopotassium salt, (+-)-isomer | malic acid, potassium salt, (r)-isomer | malic acid, (r)-isomer | malic acid, sodium salt, (+-)-isomer | salivix

Organizations (11)

Research & Development (11)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (15)

Approved Indications (1)


 

Fatigue

Experimental Indications - Clinical Trial Phases 1-4 (14)


 

Alzheimer Disease (Phase 3)

Anti-Infective Agents, Local (Phase 2)

Carcinoma, Non-Small-Cell Lung (Phase 2)

COVID-19 (Phase 2)

Depression (Phase 2/Phase 3)

Excipients ()

Hypertension (Phase 2/Phase 3)

Immune System (Phase 2)

Immunologic Factors (Phase 2)

Lung Diseases (Phase 2)

Palliative Care (Phase 2)

Quality of Life (Phase 4)

Sjogren's Syndrome (Phase 4)

Xerostomia (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 7
  • # of Trial Organizations: 11

Trials by Phase

Trial Phase Start Date Organizations Indications

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