lisofylline Report issue

Small molecule Experimental
AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

NOW
  • Now
Lisofylline (LSF) is a synthetic small molecule with novel anti-inflammatory properties. LSF can effectively prevent type 1 diabetes in preclinical models and improves the function and viability of isolated or transplanted pancreatic islets. It is a metabolite of pentoxifylline.   Wikipedia

Chemistry

  • SMILES: C[C@@H](O)CCCCn1c(=O)c2c(ncn2C)n(C)c1=O
  • InChIKey: NSMXQKNUPPXBRG-SECBINFHSA-N
  • Mol. Mass: 280.33
  • ALogP: -0.02
  • ChEMBL Molecule:
    lisofylline  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No

Alternative names

1-(5'-hydroxyhexyl)-3,7-dimethylxanthine | 1-(5r-hydroxyhexyl)-3,7-dimethylxanthine | 1h-purine-2,6-dione, 3,7-dihydro-1-(5-hydroxyhexyl)-3,7-dimethyl- | 3,7-dimethyl-1-(5-hydroxyhexyl)xanthine | a-802710 | bl 194 | ct-1501r | lisofylline | lysofylline | protec

Organizations (24)

Research & Development (24)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (4)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (4)


 

Diabetes Mellitus, Type 1 (Phase 2)

Healthy Volunteers (Phase 1/Phase 2)

Lung Diseases (Phase 3)

Respiratory Distress Syndrome (Phase 3)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 4
  • # of Trial Organizations: 24

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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