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Small molecule Experimental

AACT PubChem

Active Ingredient History

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Chemistry

SMILES: Cn1nccc1Nc1nccc(-c2cc3c(s2)C(C)(C)N(CCN2CCOCC2)C3=O)n1
InChIKey: JNPRPMBJODOFEC-UHFFFAOYSA-N
Mol. Mass: 453.57
ALogP: 2.71 Partition coefficient
ChEMBL Molecule:
temuterkib

More Chemistry

Pharmacology

Mechanisms of Action:
- Mitogen-activated protein kinase 3 (Homo sapiens) ^UniProt
- Mitogen-activated protein kinase 1 (Homo sapiens) ^UniProt
- Mitogen-activated protein kinase 1 (Homo sapiens) ^UniProt
- Mitogen-activated protein kinase 3 (Homo sapiens) ^UniProt
Multi-specific: Missing data
Black Box: No
Availability: Missing data
Delivery Methods: Missing data
Pro Drug: No

ly3214996

Organizations (11)

Research & Development (11)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (0)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (21)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (21)

Adenocarcinoma (Phase 1/Phase 2)

Biliary Tract Neoplasms (Phase 1)

Carcinoma, Non-Small-Cell Lung (Phase 1)

Colonic Neoplasms (Phase 1/Phase 2)

Colorectal Neoplasms (Phase 1/Phase 2)

Endometrial Neoplasms (Phase 1)

Glioblastoma (Early Phase 1)

Glioma (Early Phase 1)

Healthy Volunteers (Phase 1)

Leukemia, Lymphocytic, Chronic, B-Cell (Phase 1)

Leukemia, Myeloid, Acute (Phase 1)

Lymphoma, B-Cell, Marginal Zone (Phase 1)

Lymphoma, Mantle-Cell (Phase 1)

Melanoma (Phase 1)

Mutation (Phase 2)

Neoplasm Metastasis (Phase 2)

Neoplasms (Phase 2)

Ovarian Neoplasms (Phase 1)

Pancreatic Neoplasms (Phase 2)

Proto-Oncogene Proteins B-raf (Phase 2)

Waldenstrom Macroglobulinemia (Phase 1)

Overview

Highest Phase: Phase 2
# of Trials: 10
# of Trial Organizations: 11

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

Feedback

Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

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