lorlatinib (lorbrena) Report issue

Small molecule Orphan Drug FDA Approved FDA Accelerated Approval FDA Priority Review FDA
AACT ChEMBL DrugBank Drugs@FDA MeSH PubChem

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Chemistry

Mol. Mass

406.413

ALogP

2.8

Rule of 5

Yes

Rule of 3

No
Details
  • SMILES: C[C@H]1OC2=CC(=CN=C2N)C3=C(C#N)N(C)N=C3CN(C)C(=O)C4=C1C=C(F)C=C4
  • InChIKey: IIXWYSCJSQVBQM-LLVKDONJSA-N
    1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1
  • Chirality: Single Stereoisomer
  • Inorganic: No
  • Polymer: No

Sources

CHEMBL3286830   ChEMBL
lorlatinib

OSP71S83EU   NCATS
lorlatinib *

Lorlatinib   Wikipedia

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