Active Ingredient History

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Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells. This is most likely through the inhibition of the mitochondrially bound hexokinase. Later studies in Ehrlich ascites tumor cells showed that lonidamine inhibits both respiration and glycolysis leading to a decrease in cellular ATP.   Wikipedia

  • SMILES: OC(=O)c1nn(Cc2ccc(Cl)cc2Cl)c3ccccc13
  • InChIKey: WDRYRZXSPDWGEB-UHFFFAOYSA-N
  • Mol. Mass: 321.16
  • ALogP: 4.09
  • ChEMBL Molecule:
More Chemistry
1-(2,4-dichlorobenzyl)indazole-3-carboxylic acid | 1h-indazole-3-carboxylic acid, 1-((2,4-dichlorophenyl)methyl)- | af 1890 | diclondazolic acid | doridamina | lonidamine

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