levocarnitine (carnitor) Report issue

Small molecule Orphan Drug FDA Approved FDA Priority Review FDA

Active Ingredient History

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Levocarnitine propionate or Propionyl L-carnitine (PLC) is the propionyl ester of L-carnitine. Propionyl-L-carnitine stimulates energy production in ischaemic muscles by increasing citric acid cycle flux and stimulating pyruvate dehydrogenase activity. The free radical scavenging activity of the drug may also be beneficial. Propionyl-L-carnitine improves coagulative fibrinolytic homeostasis in vasal endothelium and positively affects blood viscosity. It exhibits a high affinity for the muscle enzyme, carnitine acyl transferase, and as such readily converts into propionyl-CoA and free carnitine. Most studies of the therapeutic use of PLC are focused on the prevention and treatment of ischemic heart disease, congestive heart failure, hypertrophic heart disease, and peripheral arterial disease. PLC is marketed under the trade name Dromos®. It is indicated for patients with peripheral arterial occlusive disorders and for exercise intolerance enhancement in patients with chronic congestive heart failure. Dromos is marketed in Italy.   NCATS

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Drug Pricing (per unit)

United States

$0.5863 - $13.1860
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium hydroxide, inner salt | bicarnesine | biocarn | carniking | carnilean | carnitene | carnitine | (-)-carnitine | carnitine chloride | carnitor | carnitor sf | carnivit | (-)-l-carnitine | l-carnitine | levocarnitin | levocarnitina | levocarnitine | levo-carnitine | lévocarnitine | levocarnitine chloride | levocarnitine hcl | levocarnitine hydrochloride | levocarnitine propionate | levocarnitine propionate hcl | levocarnitine propionate hydrochloride | levocarnitine tartrate | levocarnitinum | (r)-carnitine | vitamin bt

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