larotrectinib (vitrakvi) Report issue

Small molecule Orphan Drug FDA Approved FDA Accelerated Approval FDA Priority Review FDA
AACT ChEMBL Drugs@FDA MeSH PubChem

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Chemistry

Mol. Mass

428.44

ALogP

2.95

Rule of 5

Yes

Rule of 3

No
Details
  • SMILES: O[C@H]1CCN(C1)C(=O)Nc2cnn3ccc(nc23)N4CCC[C@@H]4c5cc(F)ccc5F
  • InChIKey: NYNZQNWKBKUAII-KBXCAEBGSA-N
    InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1
  • Chirality: Single Stereoisomer
  • Inorganic: No
  • Polymer: No

Sources

CHEMBL3889654   ChEMBL
larotrectinib *

CHEMBL3545075   ChEMBL

PF9462I9HX   NCATS
larotrectinib *

Larotrectinib   Wikipedia

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