fosphenytoin (Cerebyx) Report issue

Small molecule Orphan Drug FDA Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

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Fosphenytoin, also known as fosphenytoin sodium, and sold under the brand name Cerebyx among others, is a water-soluble phenytoin prodrug that is administered intravenously to deliver phenytoin, potentially more safely than intravenous phenytoin. It is used in the acute treatment of convulsive status epilepticus.   Wikipedia

Chemistry

  • SMILES: OP(=O)(O)OCN1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3
  • InChIKey: XWLUWCNOOVRFPX-UHFFFAOYSA-N
  • Mol. Mass: 362.28
  • ALogP: 1.55
  • ChEMBL Molecules:
    fosphenytoin  
    fosphenytoin sodium  
More Chemistry

Pharmacology

Drug Pricing (per unit)

United States

$2.3380 - $1000.1300
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Alternative names

2,4-imidazolidinedione, 5,5-diphenyl-3-((phosphonooxy)methyl)-, (sp-4-2)- | 3-(hydroxymethyl)phenytoin disodium phosphate | 3-(hydroxymethyl)phenytoin phosphate ester | (3-phosphoryloxymethyl)phenytoin | acc 9653 | acc-9653 | acc-9653-010 | cerebyx | ci-982 | fosfenitoina | fosphenytoin | fosphenytoin, disodium salt | fosphenytoine | fosphenytoin sodium | fosphenytoin sodium hydrate | fosphenytoinum | hmpdp | kp-413 | prodilantin | pro-epanutin

Organizations (38)

Research & Development (18)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (20)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (22)

Approved Indications (1)


 

Seizures (approved 1996)

Experimental Indications - Clinical Trial Phases 1-4 (22)


 

Astrocytoma (Phase 1)

Brain Injuries (Phase 4)

Brain Injuries, Traumatic (Phase 4)

Brain Ischemia (Phase 4)

Cancer Pain (Phase 2)

Coma (Phase 4)

Dermatitis, Atopic (Phase 1/Phase 2)

Drugs, Investigational (Phase 3)

Epilepsy ()

Glioblastoma (Phase 1)

Glioma (Phase 1)

Gliosarcoma (Phase 1)

Heart Arrest (Phase 4)

Hypoxia, Brain (Phase 4)

Hypoxia-Ischemia, Brain (Phase 4)

Intracranial Hemorrhages (Phase 4)

Oligodendroglioma (Phase 1)

Persistent Vegetative State (Phase 4)

Seizures (Phase 4)

Status Epilepticus (Phase 3)

Stroke (Phase 4)

Varicella Zoster Virus Infection (Phase 3)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 12
  • # of Trial Organizations: 18

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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