Active Ingredient History
Saridegib, also known as IPI-926, is an experimental drug candidate undergoing clinical trials for the treatment of various types of cancer, including hard-to-treat hematologic malignancies such as myelofibrosis and ligand-dependent tumors such as chondrosarcoma. IPI-926 exhibits its pharmacological effect by inhibition of the G protein-coupled receptor smoothened, a component of the hedgehog signaling pathway. Chemically, it is a semi-synthetic derivative of the alkaloid cyclopamine. The process begins with cyclopamine extracted from harvested Veratrum californicum which is taken through a series of alterations resulting in an analogue of the natural product cyclopamine, making IPI-926 the only compound in development/testing that is not fully synthetic. Wikipedia
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Basal Cell Nevus Syndrome (Phase 3)
Carcinoma, Basal Cell (Phase 2)
Chondrosarcoma (Phase 2)
Neoplasms (Phase 1)
Pancreatic Neoplasms (Phase 1/Phase 2)
Primary Myelofibrosis (Phase 2)
Squamous Cell Carcinoma of Head and Neck (Phase 1)
| Trial | Phase | Start Date | Organizations | Indications |
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