ipatasertib Report issue

Small molecule Experimental
AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

NOW
  • Now
Ipatasertib (RG7440) is an experimental cancer drug in development by Roche. It is a small molecule inhibitor of AKT, which is a key component of the PI3K/AKT pathway. Ipatasertib was discovered by Genentech in collaboration with Array Biopharma and is currently in phase II trials for treatment of breast cancer.   Wikipedia

Chemistry

  • SMILES: CC(C)NC[C@@H](C(=O)N1CCN(CC1)c2ncnc3[C@H](O)C[C@@H](C)c23)c4ccc(Cl)cc4
  • InChIKey: GRZXWCHAXNAUHY-NSISKUIASA-N
  • Mol. Mass: 458.01
  • ALogP: 3.1
  • ChEMBL Molecule:
    ipatasertib  
More Chemistry

Pharmacology

Alternative names

2-(4-chlorophenyl)-1-(4-(7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta(d)pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one | gdc-0068 | ipatasertib | rg-7440

Organizations (42)

Research & Development (42)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (27)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (27)


 

Adenocarcinoma (Phase 1)

Breast Neoplasms (Phase 3)

Carcinoma, Non-Small-Cell Lung (Phase 2)

Carcinoma, Ovarian Epithelial (Phase 1)

Carcinoma, Squamous Cell (Phase 2)

Circulating Tumor DNA (Phase 2)

Endometrial Neoplasms (Phase 2)

Fallopian Tube Neoplasms (Phase 2)

Gastrointestinal Neoplasms (Phase 2)

Glioblastoma (Phase 1/Phase 2)

Hamartoma (Phase 2)

Head and Neck Neoplasms (Phase 1)

Healthy Volunteers (Phase 1)

Hepatic Insufficiency (Phase 1)

Hypopharyngeal Neoplasms (Phase 2)

Laryngeal Neoplasms (Phase 2)

Mouth Neoplasms (Phase 2)

Neoplasm Metastasis (Phase 2)

Neoplasm, Residual (Phase 2)

Neoplasms (Phase 3)

Oropharyngeal Neoplasms (Phase 2)

Ovarian Neoplasms (Phase 2)

Prostatic Neoplasms (Phase 2)

Prostatic Neoplasms, Castration-Resistant (Phase 1/Phase 2)

Squamous Cell Carcinoma of Head and Neck (Phase 2)

Stomach Neoplasms (Phase 2)

Triple Negative Breast Neoplasms (Phase 3)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 55
  • # of Trial Organizations: 42

Trials by Phase

Trial Phase Start Date Organizations Indications

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