rocuronium (zemuron) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem

Active Ingredient History

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Rocuronium (brand names Zemuron, Esmeron) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anesthesia to facilitate endotracheal intubation by providing skeletal muscle relaxation, most commonly required for surgery or mechanical ventilation. Rocuronium bromide is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration. It acts by competing for cholinergic receptors at the motor end-plate. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine and edrophonium. Most common adverse reactions are transient hypotension and hypertension.   NCATS

Chemistry

  • SMILES: CC(=O)O[C@H]1[C@H](C[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@H](C[C@]4(C)[C@H]3CC[C@]12C)N5CCOCC5)[N+]6(CC=C)CCCC6
  • InChIKey: YXRDKMPIGHSVRX-OOJCLDBCSA-N
  • Mol. Mass: 529.79
  • ALogP: 4.41
  • ChEMBL Molecules:
    rocuronium  
    rocuronium bromide  
More Chemistry

Pharmacology

Drug Pricing (per unit)

United States

$2.5950 - $6.5360
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Alternative names

1-(17-(acetoyl)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl)-1-(2-propenyl)pyrrolidinium | (17 beta)-2-methoxyestra-1,3,5(10)-triene-3,17-diol | 2-hydroxyestradiol 2-methyl ether | 2-hydroxyestradol 2-methyl ether | 2me2 | 2-meoe2 | 2-methoxy-17beta-estradiol | 2-methoxyestra-1(10),2,4-triene-3,17-diol | 2-methoxyestradiol | 2-methoxyestradiol, (17alpha)-isomer | 2-methoxyestradiol-17beta | 2-methoxyestradiol-17 beta | 2-methoxyoestradiol | 2-(methyl-11c)methoxyestradiol | esm | esmeron | esmerone | nmba | org 9426 | org-9426 | panzem | pyrrolidinium, 1-((2beta,3alpha,5alpha,16beta,17beta)-17-(acetyloxy)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl)-1-(2-propenyl)-, bromide | rocuronbromid | rocuronium | rocuronium bromide | zemuron

Organizations (203)

Research & Development (182)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (21)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (112)

Approved Indications (1)


 

Somatoform Disorders (approved 1994)

Experimental Indications - Clinical Trial Phases 1-4 (111)


 

Acute-On-Chronic Liver Failure (Phase 4)

Airway Management (Phase 4)

Analgesia (Phase 4)

Analgesics, Opioid (Phase 4)

Anesthesia (Phase 4)

Anesthesia and Analgesia (Phase 4)

Anesthesia, General (Phase 4)

Anesthesia, Local (Phase 3)

Anesthesia, Spinal (Phase 4)

Appendicitis (Phase 3)

Arthritis (Phase 4)

Arthroplasty, Replacement, Hip (Phase 4)

Back Pain (Phase 3)

Bariatric Surgery (Phase 4)

Carcinoid Tumor (Phase 2)

Carcinoma, Renal Cell (Phase 2)

Cesarean Section (Phase 4)

Cholecystectomy, Laparoscopic (Phase 4)

Cholecystitis (Phase 4)

Colorectal Surgery (Phase 4)

Coma (Phase 4)

Coronary Artery Disease (Phase 4)

Delayed Emergence from Anesthesia (Phase 4)

Delirium (Early Phase 1)

Diaphragm (Phase 3)

Drug-Related Side Effects and Adverse Reactions (Phase 4)

Endometriosis (Phase 4)

Epigenomics (Phase 4)

Esophageal and Gastric Varices (Phase 4)

Esophageal Neoplasms (Phase 4)

Extracorporeal Membrane Oxygenation (Phase 4)

Fractures, Bone (Early Phase 1)

Gallbladder Diseases (Phase 4)

Gastric Bypass (Phase 4)

Gastrointestinal Neoplasms (Phase 4)

General Surgery (Phase 4)

Glioblastoma (Phase 2)

Gynecology (Phase 4)

Heart Arrest (Phase 2)

Heart Defects, Congenital (Phase 4)

Heart Diseases (Phase 3)

Hemodynamics (Phase 4)

Hernia, Inguinal (Phase 4)

High-Frequency Jet Ventilation (Phase 1)

Hip Fractures (Phase 4)

Hypothermia (Phase 3)

Hypoxia (Phase 4)

Hysterectomy (Phase 4)

Immune System Diseases (Phase 4)

Inflammation (Phase 4)

Inhalation (Phase 4)

Intensive Care Units (Phase 4)

Intestinal Diseases (Phase 4)

Intestinal Pseudo-Obstruction (Phase 4)

Intraocular Pressure (Phase 4)

Intraoperative Awareness (Phase 4)

Intubation (Phase 4)

Intubation, Intratracheal (Phase 4)

Kidney Diseases (Phase 4)

Kidney Failure, Chronic (Phase 2)

Kidney Transplantation (Phase 4)

Laparoscopy (Phase 4)

Laryngeal Masks (Phase 4)

Laryngoscopy (Phase 4)

Leiomyoma (Phase 4)

Lung Diseases (Phase 4)

Lung Neoplasms (Phase 2/Phase 3)

Multiple Myeloma (Phase 2)

Muscle Fatigue (Phase 3)

Muscle Relaxants, Central (Phase 4)

Muscle Relaxation (Phase 4)

Muscle Weakness (Phase 3)

Myalgia (Phase 3)

Myoclonus (Phase 4)

Nausea (Phase 4)

Neoplasm Metastasis (Phase 4)

Neoplasms (Phase 4)

Nerve Block (Phase 3)

Neuromuscular Blockade (Phase 4)

Obesity (Phase 4)

Obesity, Morbid (Phase 4)

Organophosphate Poisoning (Phase 2/Phase 3)

Osteoarthritis (Phase 4)

Out-of-Hospital Cardiac Arrest (Phase 2)

Ovarian Neoplasms (Phase 2)

Pain (Phase 4)

Pain, Postoperative (Phase 4)

Pancreatic Neoplasms (Phase 3)

Pathology (Phase 4)

Pneumoperitoneum (Phase 4)

Postoperative Complications (Phase 4)

Pregnancy (Phase 4)

Prostatic Neoplasms (Phase 4)

Quality of Life (Phase 4)

Rapid Sequence Induction and Intubation (Phase 4)

Renal Insufficiency, Chronic (Phase 4)

Respiratory Distress Syndrome (Phase 4)

Respiratory Insufficiency (Phase 4)

Rotator Cuff Injuries (Phase 4)

Shock (Phase 4)

Spinal Diseases (Phase 4)

Spinal Fusion (Phase 3)

Spinal Stenosis (Early Phase 1)

Tracheostomy (Phase 4)

Traumatology (Phase 4)

Urinary Bladder Neoplasms (Phase 4)

Urologic Diseases (Phase 4)

Uterine Prolapse (Phase 4)

Vascular Diseases (Phase 4)

Vocal Cord Dysfunction (Phase 1)

Vomiting (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 238
  • # of Trial Organizations: 182

Trials by Phase

Trial Phase Start Date Organizations Indications

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