epacadostat Report issue

Small molecule Experimental
AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

NOW
  • Now
Epacadostat is an investigational drug for cancer. Epacadostat is an inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1). Epacadostat inhibits IDO1 by competitively blocking it, without interfering with IDO2 or tryptophan 2,3-dioxygenase (TDO). It has antitumor activity in some models, though is most effective when combined with other immunotherapy agents.   Wikipedia

Chemistry

  • SMILES: NS(=O)(=O)NCCNc1nonc1\C(=N\O)\Nc2ccc(F)c(Br)c2
  • InChIKey: FBKMWOJEPMPVTQ-UHFFFAOYSA-N
  • Mol. Mass: 438.24
  • ALogP: 0.42
  • ChEMBL Molecule:
    epacadostat  
More Chemistry

Pharmacology

Alternative names

epacadostat | incb024360 | incb-024360

Organizations (40)

Research & Development (40)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (37)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (37)


 

BRCA1 Protein (Phase 2)

Breast Neoplasms (Phase 1/Phase 2)

Carcinoma, Hepatocellular (Phase 1/Phase 2)

Carcinoma, Non-Small-Cell Lung (Phase 1)

Carcinoma, Renal Cell (Phase 3)

Carcinoma, Transitional Cell (Phase 3)

Colorectal Neoplasms (Phase 1/Phase 2)

Endometrial Neoplasms (Phase 2)

Epstein-Barr Virus Infections (Phase 2)

Esophageal Neoplasms (Phase 2)

Esophageal Squamous Cell Carcinoma (Phase 2)

Fallopian Tube Neoplasms (Phase 1/Phase 2)

Gastrointestinal Stromal Tumors (Phase 2)

Glioblastoma (Phase 1/Phase 2)

Glioma (Phase 1/Phase 2)

Hamartoma (Phase 1/Phase 2)

Head and Neck Neoplasms (Phase 3)

Homologous Recombination (Phase 2)

Leukemia, B-Cell (Phase 1/Phase 2)

Leukemia, Myeloid, Acute (Phase 1)

Lung Neoplasms (Phase 3)

Lymphoma (Phase 1/Phase 2)

Melanoma (Phase 3)

Mutation (Phase 2)

Myelodysplastic Syndromes (Phase 2)

Nasopharyngeal Carcinoma (Phase 2)

Neoplasms (Phase 2)

Ovarian Neoplasms (Phase 2)

Pancreatic Neoplasms (Phase 2)

Prostatic Neoplasms (Phase 1/Phase 2)

Rectal Neoplasms (Phase 1/Phase 2)

Recurrence (Phase 1)

Sarcoma (Phase 2)

Small Cell Lung Carcinoma (Phase 2)

Squamous Cell Carcinoma of Head and Neck (Phase 2)

Stomach Neoplasms (Phase 2)

Urinary Bladder Neoplasms (Phase 2)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 59
  • # of Trial Organizations: 40

Trials by Phase

Trial Phase Start Date Organizations Indications

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