Active Ingredient History

NOW
  • Now
Idarubicin is an antineoplastic in the anthracycline class.Idarubicin hydrochloride is a DNA-intercalating analog of daunorubicin which has an inhibitory effect on nucleic acid synthesis and interacts with the enzyme topoisomerase II. The absence of a methoxy group at position 4 of the anthracycline structure gives the compound a high lipophilicity which results in an increased rate of cellular uptake compared with other anthracyclines.Idarubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. Idarubicin in combination with other approved antileukemic drugs is indicated for the treatment of acute myeloid leukemia (AML) in adults.   NCATS

  • SMILES: C[C@@H]1O[C@H](C[C@H](N)[C@@H]1O)O[C@H]2C[C@@](O)(Cc3c(O)c4C(=O)c5ccccc5C(=O)c4c(O)c23)C(=O)C
  • InChIKey: XDXDZDZNSLXDNA-TZNDIEGXSA-N
  • Mol. Mass: 497.5
  • ALogP: 1.02
  • ChEMBL Molecules:
More Chemistry
  • Mechanisms of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Parenteral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$5.8845 - $9.5010

Australia

$23.1892
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

(1s,3s)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydronaphthacen-1-yl 3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranoside | 4-demethoxydaunomycin | 4-demethoxydaunorubicin | 5,12-naphthacenedione, 9-acetyl-7-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, (7s-cis)- | demethoxydaunorubicin | idamycin | idamycin pfs | idarubcin | idarubicin | idarubicina | idarubicine | idarubicin hcl | idarubicin hydrochloride | idarubicin hydrochloride pfs | idarubicinum | imi-30 | zavedos

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