ibipinabant Report issue

Small molecule Experimental
AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

NOW
  • Now
Ibipinabant (SLV319, BMS-646,256) is a drug used in scientific research which acts as a potent and highly selective CB1 antagonist. It has potent anorectic effects in animals, and was researched for the treatment of obesity, although CB1 antagonists as a class have now fallen out of favour as potential anorectics following the problems seen with rimonabant, and so ibipinabant is now only used for laboratory research, especially structure-activity relationship studies into novel CB1 antagonists. SLV330, which is a structural analogue of Ibipinabant, was reported active in animal models related to the regulation of memory, cognition, as well as in addictive behavior. An atom-efficient synthesis of ibipinabant has been reported.   Wikipedia

Chemistry

  • SMILES: CN/C(=N\S(=O)(=O)c1ccc(Cl)cc1)N1C[C@H](c2ccccc2)C(c2ccc(Cl)cc2)=N1
  • InChIKey: AXJQVVLKUYCICH-OAQYLSRUSA-N
  • Mol. Mass: 487.41
  • ALogP: 4.76
  • ChEMBL Molecule:
    ibipinabant  
More Chemistry

Pharmacology

Alternative names

3-(4-chlorophenyl)-n-((4-chlorophenyl)sulfonyl)-4,5-dihydro-n'-methyl-4-phenyl-1h-pyrazole-1-carboximidamide | 3-(4-chlorophenyl)-n-methyl-n'-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1h-pyrazole-1-carboxamidine | bms-646256 | ibipinabant | slv319 | slv 319 | slv-319

Organizations (2)

Research & Development (2)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (1)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (1)


 

Obesity (Phase 2/Phase 3)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 2
  • # of Trial Organizations: 2

Trials by Phase

Trial Phase Start Date Organizations Indications

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