Active Ingredient History

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Hydroquinone, aka benzene-1,4-diol or quinol, is an aromatic organic compound that is a type of phenol, a derivative of benzene, having the chemical formula C6H4(OH)2. Its chemical structure features two hydroxyl groups bonded to a benzene ring in a para position. It is a white granular solid. Substituted derivatives of this parent compound are also referred to as hydroquinones. The name "hydroquinone" was coined by Friedrich Wöhler in 1843. In human medicine, hydroquinone is used as a topical application in skin whitening to reduce the color of skin. It does not have the same predisposition to cause dermatitis as metol does. In 2006, the United States Food and Drug Administration revoked its previous approval of hydroquinone and proposed a ban on all over-the-counter preparations. The FDA stated that hydroquinone cannot be ruled out as a potential carcinogen. This conclusion was reached based on the extent of absorption in humans and the incidence of neoplasms in rats in several studies where adult rats were found to have increased rates of tumours, including thyroid follicular cell hyperplasias, anisokaryosis (variation in nuclei sizes), mononuclear cell leukemia, hepatocellular adenomas and renal tubule cell adenomas. One of the components in TRI-LUMA Cream, hydroquinone, is a depigmenting agent, and may interrupt one or more steps in the tyrosine-tyrosinase pathway of melanin synthesis. However, the mechanism of action of the active ingredients in TRI-LUMA Cream in the treatment of melasma is unknown.   NCATS

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Drug Pricing (per unit)

United States

$0.9174 - $1.7729
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

1,4-benzenediol | 1,4-dihydroxybenzene | 205 e | 4-hydroxyphenol | 4-hydroxyphenyl-beta-d-glucopyranoside | arbutin | arbutine | arbutoside | arbutyne | artra | benzene-1,4-diol | beta-quinol | black and white | black and white bleaching cream | calcium dobesilate | calcium doxybensylate | dexium | dobesilate | dobesilate calcium | doxium | doxium 500 | eldopaque | eldopaque forte | eldoquin | eldoquin forte | esoterica | glyhexylamide | glyhexylamine isodiane | hidroquilaude | hidroquin | hidroquinona isdin | hydroquinone | hydroquinone calcium sulfate | hydroquinone calcium sulfonate | hydroquinone, copper (1+) salt | hydroquinone glucose | hydroquinone, lead (2+) salt (2:1) | hydroquinone, monocopper (2+) salt | icn brand 1 of hydroquinone | icn brand 2 of hydroquinone | icn brand 3 of hydroquinone | icn brand 4 of hydroquinone | idrochinone | licostrata | lustra | melanasa | melanex | melpaque | melquin | metahexamide | methahexamide | methexamide | neostrata hq | p-benzenediol | phiaquin | p-hydroquinone | p-hydroxyphenol | plough brand 1 of hydroquinone | plough brand 2 of hydroquinone | quinol | solaquin | solaquin forte | stratus brand 1 of hydroquinone | stratus brand 2 of hydroquinone | ultraquin

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