Active Ingredient History
Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Warfarin is marketed under the brand name Coumadin among others. Coumadin (crystalline warfarin sodium) is an anticoagulant which acts by inhibiting vitamin K-dependent coagulation factors. Chemically, it is 3-(α-acetonylbenzyl)-4-hydroxycoumarin and is a racemic mixture of the R- and S-enantiomers. Coumadin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, and pulmonary embolism. It is also indicated for the prophylaxis and/or treatment of the thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement. Warfarin is thought to interfere with clotting factor synthesis by inhibition of the C1 subunit of the vitamin K epoxide reductase (VKORC1) enzyme complex, thereby reducing the regeneration of vitamin K1 epoxide. The degree of depression is dependent upon the dosage administered and, in part, by the patient’s VKORC1 genotype. Therapeutic doses of warfarin decrease the total amount of the active form of each vitamin K dependent clotting factor made by the liver by approximately 30% to 50%. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Myocardial Infarction (approved 1954)
Thromboembolism (approved 1954)
Venous Thrombosis (approved 1954)
Abortion, Habitual (Phase 4)
Acute Coronary Syndrome (Phase 4)
Alzheimer Disease (Phase 1)
Anticoagulants (Phase 4)
Antiphospholipid Syndrome (Phase 4)
Aortic Valve Disease (Phase 4)
Aortic Valve Insufficiency (Phase 4)
Aortic Valve Stenosis (Phase 4)
Appendix (Phase 4)
Arrhythmias, Cardiac (Phase 3)
Arterial Occlusive Diseases (Phase 3)
Arthritis, Rheumatoid (Phase 1)
Arthroplasty (Phase 4)
Arthroplasty, Replacement, Knee (Phase 2)
Atherosclerosis (Phase 4)
Atrial Flutter (Phase 3)
Blood Coagulation (Phase 4)
Blood Coagulation Disorders (Phase 4)
Blood Loss, Surgical (Phase 4)
Blood Platelets (Phase 4)
Body Weight (Phase 1)
Brain Infarction (Phase 3)
Brain Ischemia (Phase 2/Phase 3)
Cardiomyopathies (Phase 2/Phase 3)
Cardiovascular Diseases (Phase 4)
Carotid Artery Diseases (Phase 3)
Cerebral Infarction (Phase 3)
Cerebral Intraventricular Hemorrhage (Phase 3)
Cerebrovascular Disorders (Phase 4)
Cervix Uteri (Phase 3)
Cognition Disorders (Phase 4)
Colitis, Ulcerative (Phase 1)
Constriction, Pathologic (Phase 3)
Coronary Aneurysm (Phase 3)
Coronary Artery Bypass (Phase 2/Phase 3)
Coronary Artery Disease (Phase 4)
Coronary Disease (Phase 3)
Crohn Disease (Phase 1)
Cytochrome P-450 Enzyme System (Phase 1)
Dementia (Phase 4)
Depressive Disorder, Major (Phase 1)
Dermatitis, Atopic (Phase 1)
Diabetes Mellitus (Phase 4)
Diabetes Mellitus, Type 2 (Phase 1)
Drug Interactions (Phase 1)
Drug Therapy, Combination (Phase 4)
Electric Countershock (Phase 3)
Embolic Stroke (Phase 3)
Embolism (Phase 4)
Embolism and Thrombosis (Phase 2)
Epilepsy (Phase 1)
Esophageal and Gastric Varices (Phase 4)
Essential Hypertension (Phase 1)
Fibrinolytic Agents (Phase 3)
Fibrosis (Phase 4)
Foramen Ovale, Patent (Phase 4)
General Surgery (Phase 4)
Healthy Volunteers (Phase 4)
Heart Defects, Congenital (Phase 4)
Heart Diseases (Phase 4)
Heart Failure (Phase 4)
Heart Valve Diseases (Phase 4)
Heart Valve Prosthesis (Phase 2)
Hematologic Neoplasms (Phase 1)
Hematoma (Phase 4)
Hematoma, Subdural (Phase 3)
Hemorrhage (Phase 4)
Hemostasis (Phase 1)
Hepatitis B, Chronic (Phase 1)
Huntington Disease (Phase 1)
Hypertension (Phase 4)
Hypertension, Portal (Phase 4)
Hypertension, Pulmonary (Phase 3)
Hypertriglyceridemia (Phase 1)
Hypertrophy, Left Ventricular (Phase 4)
Hypoprothrombinemias (Phase 1/Phase 2)
Idiopathic Pulmonary Fibrosis (Phase 3)
Intestinal Neoplasms (Phase 4)
Intracranial Embolism and Thrombosis (Phase 3)
Intracranial Hemorrhage, Hypertensive (Phase 3)
Intracranial Hemorrhages (Phase 3)
Ischemia (Phase 4)
Ischemic Attack, Transient (Phase 4)
Ischemic Stroke (Phase 4)
Kidney Failure, Chronic (Phase 4)
Lipoproteins (Phase 1)
Liver Cirrhosis (Phase 4)
Lupus Erythematosus, Systemic (Phase 2/Phase 3)
Lymphoma (Phase 1)
May-Thurner Syndrome (Phase 3)
Melanoma (Phase 1)
MINOCA (Phase 4)
Mitral Valve (Phase 4)
Mitral Valve Stenosis (Phase 4)
Mucocutaneous Lymph Node Syndrome (Phase 3)
Multiple Sclerosis, Relapsing-Remitting (Phase 3)
Myocardial Infarction (Phase 4)
Myocardial Ischemia (Phase 3)
Neoplasm Metastasis (Phase 1)
Neoplasms (Phase 3)
Non-alcoholic Fatty Liver Disease (Phase 1)
Obesity (Phase 1)
Oligohydramnios (Phase 4)
Osteoarthritis, Knee (Phase 1)
Pancreatic Neoplasms (Early Phase 1)
Parkinson Disease (Phase 1)
Percutaneous Coronary Intervention (Phase 3)
Peripheral Vascular Diseases (Phase 3)
Pharmacokinetics (Phase 1)
Pharmacology (Phase 1)
Portal Vein (Phase 3)
Postoperative Complications (Phase 2/Phase 3)
Postthrombotic Syndrome (Phase 3)
Pregnancy Complications (Phase 3)
Prostatic Neoplasms (Phase 3)
Prostheses and Implants (Phase 2/Phase 3)
Psoriasis (Phase 1)
Pulmonary Arterial Hypertension (Phase 1)
Pulmonary Embolism (Phase 4)
Renal Insufficiency, Chronic (Phase 4)
Rheumatic Heart Disease (Phase 3)
Rivaroxaban (Phase 3)
Splenectomy (Phase 4)
ST Elevation Myocardial Infarction (Phase 3)
Stroke (Phase 4)
Subarachnoid Hemorrhage (Phase 3)
Thrombocytopenia (Phase 3)
Thromboembolism (Phase 4)
Thrombophlebitis (Phase 3)
Thrombosis (Phase 4)
Upper Extremity Deep Vein Thrombosis (Phase 4)
Urinary Bladder, Overactive (Phase 1)
Vascular Diseases (Phase 3)
Venous Thromboembolism (Phase 3)
Venous Thrombosis (Phase 4)
Vertebral Artery Dissection (Phase 3)
Volunteers (Phase 1)
Warfarin (Phase 3)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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