photochlor Report issue

Small molecule Experimental
AACT MeSH PubChem

Active Ingredient History

NOW
  • Now
2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH), a chlorin-based photosensitize, is used in photodynamic therapy. It has been shown the therapeutic potential of HPPH in phase II clinical trials for the treatment of esophageal cancer. Besides, HPPH participated in clinical trials in treating patients with advanced non-small cell lung cancer that blocks the air passages. However, these studies were terminated.   NCATS

Chemistry

  • SMILES: CCCCCCOC(C)C1=C(C)C2=CC3=NC([C@@H](CCC(O)=O)[C@@H]3C)=C4CC(=O)C5=C4NC(C=C6N=C(C=C1N2)C(C)=C6CC)=C5C
  • InChIKey: PVXGCBZIVFCMJK-NMWXTPPCSA-N
  • Mol. Mass: 636.8228
  • ALogP: Missing data
  • ChEMBL Molecules: Missing data
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Missing data
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: Missing data

Alternative names

2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a | hpph | photochlor

Organizations (2)

Research & Development (2)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (26)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (26)


 

Adenocarcinoma of Lung (Phase 1)

Barrett Esophagus (Phase 1)

Bronchopulmonary Dysplasia (Phase 1)

Carcinoma, Adenoid Cystic (Phase 1)

Carcinoma, Basal Cell (Phase 1)

Carcinoma, Mucoepidermoid (Phase 1)

Carcinoma, Non-Small-Cell Lung (Phase 1)

Carcinoma, Squamous Cell (Phase 2)

Carcinoma, Verrucous (Phase 2)

Developmental Dysplasia of the Hip (Phase 1)

Esophageal Neoplasms (Phase 2)

Graft vs Host Disease (Phase 1)

Granuloma (Phase 1)

Head and Neck Neoplasms (Phase 1)

Lung Neoplasms (Phase 2)

Melanoma (Phase 1)

Nasopharyngeal Neoplasms (Phase 1)

Neoplasm Metastasis (Phase 1)

Neoplasms (Phase 1)

Neuroblastoma (Phase 1)

Oropharyngeal Neoplasms (Phase 1)

Papilloma, Inverted (Phase 1)

Precancerous Conditions (Phase 2)

Salivary Gland Neoplasms (Phase 1)

Squamous Cell Carcinoma of Head and Neck (Phase 2)

Thyroid Neoplasms (Phase 1)

Overview

  • Highest Phase: Phase 2
  • # of Trials: 16
  • # of Trial Organizations: 2

Trials by Phase

Trial Phase Start Date Organizations Indications

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