Active Ingredient History

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Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms. Famotidine binds competitively to H2-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.   NCATS

  • SMILES: NC(=N)NC1=NC(CSCCC(=N)NS(N)(=O)=O)=CS1
  • InChIKey: XUFQPHANEAPEMJ-UHFFFAOYSA-N
  • Mol. Mass: 337.445
  • ALogP: -0.77
  • ChEMBL Molecule:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Over the Counter
  • Delivery Methods: Oral, Parenteral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.0506 - $7.6800

Australia

$0.0516 - $0.1031
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

(1-amino-3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)propylidene)sulfamide | 3-(((2-((aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-n-(aminosulfonyl)propanimidamide | 3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)-n(sup 2)-sulfamoylpropionamidine | agufam | amfamox | antodine | apogastine | bestidine | brolin | cepal | digervin | dispromil | famotidina | famotidine | famotidinum | fluxid | mk-2048 | mk-208 | n-sulfamoyl-3-((2-guanidinothiazol-4-yl)methylthio)propionamide | pepcid | pepcid ac | pepcid rpd

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