Active Ingredient History

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Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer (levonorgestrel) is biologically active. Norgestrel (and more specifically the active stereoisomer levonorgestrel) binds to the progesterone and estrogen receptors within the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like levonorgestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. Loss of the LH surge inhibits ovulation and thereby prevents pregnancy. Norgestrel in combination with ethinyl estradiol is indicated for the prevention of pregnancy in women who elect to use this product as a method of contraception.   NCATS

  • SMILES: CC[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@H]34)[C@@H]1CC[C@@]2(O)C#C
  • InChIKey: WWYNJERNGUHSAO-XUDSTZEESA-N
  • Mol. Mass: 312.4458
  • ALogP: 3.88
  • ChEMBL Molecules:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Over the Counter
  • Delivery Methods: Oral, Parenteral, Topical
  • Pro Drug: No

Combination drugs

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( norgestrel (Ovral), ethinyl estradiol (Estinyl) - other names: afirmelle, alesse, altavera, ashlyna, aviane, ayuna, balcoltra, cerinta, cryselle, daysee, elifemme, elinest, enpresse, falmina, fayosim, iclevia, introvale, jaimiess, kurvelo, lessina, levlite, levonest, levonorgestrel and ethinyl estradiol and ethinyl estradiol, levora, lo/ovral, loseasonique, lo simpesse, low-ogestrel, lybrel, marlissa, myzilra, nordette, ogestrel, orsythia, portia, preven emergency contraceptive, quartette, quasense, seasonale, seasonique, setlakin, simpesse, sylevia, triphasil, trivora, vienva )
13-beta-ethyl-17alpha-ethynyl-17beta-hydroxygon-4-en-3-one | 13-ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one | 13-ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one | (-)-13-ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one | 17-alpha-ethinyl-13-beta-ethyl-17-beta-hydroxy-4-estren-3-one | 17alpha-ethynyl-13beta-ethyl-3-oxo-4-estren-17beta-ol | 17-alpha-ethynyl-13-ethyl-19-nortestosterone | 17alpha-ethynyl-17-hydroxy-18-methylestr-4-en-3-one | 17alpha-ethynyl-18-homo-19-nortestosterone | 17-ethynyl-17-hydroxy-18a-homoestr-4-en-3-one | 17-ethynyl-18-methyl-19-nortestosterone | 18-methyl-17-alpha-ethynyl-19-nortestosterone | 18-methylnorethindrone | 18-methylnorethisterone | (8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy- 1,2,6,7,8,9,10,11,12,13,14,15,16, 17- tetradecahydrocyclopenta[a] phenanthren-3-one | dexnorgestrel | d-norgestrel | d(-)-norgestrel | emerres | emerres una | ezinelle | isteranda | jadelle | jaydess | ld norgestrel | levonelle | levonelle-2 | levonelle one step | levongestrel | levonorgestrel | lévonorgestrel | levonorgestrelum | levonova | levosert | methylnorethindrone | microlut | microluton | microval | mirena | nordette | norgeston | norgestrel | norlevo | norplant | norplant ii | norplant system | ovral | ovrette | plan b | plan b one-step | postinor | postinor-2 | prefest | previfem | skyla | sprintec | tri-previfem | tri-sprintec | upostelle | wy-3707 | wy-5104

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