glimepiride (amaryl) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Glimepiride, like glyburide and glipizide, is a "second-generation" sulfonylurea agents. Glimepiride is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin. The mechanism of action of glimepiride in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Glimepiride likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin. Glimepiride is used for concomitant use with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus. Glimepiride`s original trade name is Amaryl.   NCATS

Chemistry

  • SMILES: CCC1=C(C)CN(C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)N[C@H]3CC[C@H](C)CC3)C1=O
  • InChIKey: WIGIZIANZCJQQY-RUCARUNLSA-N
  • Mol. Mass: 490.616
  • ALogP: 3.07
  • ChEMBL Molecules:
    glimepiride  
    gemigliptin  
More Chemistry

Pharmacology

Drug Pricing (per unit)

Australia

$0.0339 - $0.1328

United States

$0.0388 - $4.0825
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

( glimepiride (amaryl), rosiglitazone )
|
( glimepiride (amaryl), pioglitazone (actos) )

Alternative names

1-(4-(2-(3-ethyl-4-methyl-2-oxo-3-pyrrolinecarboxamido)ethyl)phenylsulfonyl)-3-(4-methylcyclohexyl)urea | amarel | amaryl | aventis behring brand of glimepiride | aventis brand of glimepiride | aventis pharma brand of glimepiride | diameprid | gemigliptin | glimax | glimepirida | glimepiride | glimépiride | glimepiridum | glimperide | glirid | glymepiride | hoe 490 | hoe-490 | hoechst brand of glimepiride | lacer brand of glimepiride | lc15-0444 | ls15-0444 | niddaryl | n,n-dimethyl-5-((2-methyl-6-((5-methylpyrazin-2-yl)carbamoyl)benzofuran-4-yl)oxy)pyrimidine-2-carboxamide | pf-04937319 | pioglitazone / glimepiride | roname | rosiglitazone / glimepiride | zemiglo

Organizations (156)

Research & Development (141)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (23)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (33)

Approved Indications (2)


 

Diabetes Mellitus

Diabetes Mellitus, Type 2

Experimental Indications - Clinical Trial Phases 1-4 (33)


 

Acarbose (Phase 4)

Albuminuria (Phase 4)

Atherosclerosis (Phase 3)

Cardiovascular Diseases (Phase 4)

Cellular Senescence (Phase 4)

Coronary Artery Disease (Phase 4)

Coronary Disease (Phase 3)

Diabetes Mellitus ()

Diabetes Mellitus, Type 2 ()

Diabetic Foot (Phase 2)

Drug-Related Side Effects and Adverse Reactions (Phase 4)

Drugs, Investigational (Phase 4)

Dyslipidemias (Phase 3)

Endothelial Cells (Phase 4)

Endothelium (Phase 4)

Glycemic Control (Phase 4)

Healthy Volunteers (Phase 1)

Heart Disease Risk Factors (Phase 4)

Heart Failure (Phase 2)

Hypercholesterolemia (Phase 3)

Hypertension (Phase 3)

Hypoglycemia (Phase 4)

Insulin Resistance (Phase 4)

Kidney Diseases (Phase 3)

Liver Diseases (Phase 1)

Metabolic Syndrome (Phase 3)

Neoplasms (Phase 2/Phase 3)

Non-alcoholic Fatty Liver Disease (Phase 4)

Pancreatic Neoplasms (Phase 4)

Pharmacokinetics (Phase 1)

Polycystic Ovary Syndrome (Phase 3)

Sodium-Glucose Transporter 2 Inhibitors (Phase 4)

Stroke Volume (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 246
  • # of Trial Organizations: 141

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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