Active Ingredient History
Ciprofloxacin (1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid) is the synthetic antimicrobial agent for oral or intravenous administration. Ciprofloxacin is a member of the fluoroquinolone class of antibacterial agents. The bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV (both Type II topoisomerases), which are required for bacterial DNA replication, transcription, repair, and recombination. Ciprofloxacin is used to treat a wide variety of infections, including infections of bones and joints, endocarditis, gastroenteritis, malignant otitis externa, respiratory tract infections, cellulitis, urinary tract infections, prostatitis, anthrax, and chancroid. In the United States, ciprofloxacin is pregnancy category C. This category includes drugs for which no adequate and well-controlled studies in human pregnancy exist, and for which animal studies have suggested the potential for harm to the fetus, but potential benefits may warrant use of the drug in pregnant women despite potential risks. Fluoroquinolones have been reported as present in a mother's milk and thus passed on to the nursing child. Oral and intravenous ciprofloxacin is approved by the FDA for use in children for only two indications due to the risk of permanent injury to the musculoskeletal system: Inhalational anthrax (postexposure) and Complicated urinary tract infections and pyelonephritis due to Escherichia coli. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Dysentery (approved 1990)
Respiratory Tract Infections (approved 1990)
Abscess (Phase 3)
Agammaglobulinemia (Phase 2/Phase 3)
Alopecia (Phase 2)
Alopecia Areata (Phase 2)
Alzheimer Disease (Phase 2)
Amyotrophic Lateral Sclerosis (Phase 2)
Anastomotic Leak (Phase 2)
Anthrax (Phase 2)
Anti-Bacterial Agents (Phase 4)
Appendicitis (Phase 4)
Arm Injuries (Phase 4)
Arthritis, Rheumatoid (Phase 1)
Ascites (Phase 4)
Asthma (Phase 4)
Bacteremia (Phase 3)
Bacterial Infections (Phase 4)
Bacteriuria (Phase 4)
BK Virus (Phase 4)
Bone Diseases, Infectious (Phase 4)
Brain Injuries (Phase 2)
Brain Neoplasms (Phase 3)
Breast Neoplasms (Phase 4)
Bronchiectasis (Phase 4)
Burns (Phase 3)
Carcinoma, Squamous Cell (Phase 2)
Cataract (Phase 4)
Cerebrospinal Fluid Otorrhea (Phase 4)
Chlamydia trachomatis (Phase 4)
Cholelithiasis (Phase 4)
Cholera (Phase 3)
Chronic Periodontitis (Phase 4)
Colitis, Ulcerative (Phase 4)
Communicable Diseases (Phase 3)
Community-Acquired Infections (Phase 4)
Conjunctivitis (Phase 1)
Conjunctivitis, Bacterial (Phase 1)
Corneal Injuries (Phase 2)
Corneal Ulcer (Phase 2)
Critical Illness (Phase 4)
Crohn Disease (Phase 4)
Cross Infection (Phase 2)
Cyclophosphamide (Phase 3)
Cystic Fibrosis (Phase 4)
Cystitis (Phase 4)
Dental Pulp (Phase 2/Phase 3)
Dental Pulp Necrosis (Phase 4)
Diabetic Foot (Phase 1/Phase 2)
Diarrhea (Phase 4)
Diverticulitis (Phase 3)
Doxorubicin (Phase 3)
Dysbiosis (Phase 1)
Dysentery, Bacillary (Phase 4)
Ear Diseases (Phase 2)
Endocarditis (Phase 4)
Endometrial Neoplasms (Phase 2)
Endophthalmitis (Phase 2)
Enterobacteriaceae Infections (Phase 3)
Escherichia coli Infections (Phase 2)
Fasting (Phase 1)
Fear (Phase 2/Phase 3)
Febrile Neutropenia (Phase 4)
Fever (Phase 4)
Fibrosis (Phase 4)
Gonorrhea (Phase 4)
Granulomatosis, Orofacial (Phase 2)
Hand Injuries (Phase 4)
Head and Neck Neoplasms (Phase 2)
Healthy Volunteers (Phase 1)
Hearing Loss (Phase 1/Phase 2)
Hematopoietic Stem Cell Transplantation (Phase 2)
Hepacivirus (Phase 1)
Hepatitis, Alcoholic (Early Phase 1)
HIV (Phase 4)
HIV Infections (Phase 2)
Hypoglycemia (Phase 4)
Infections ()
Intestinal Neoplasms (Phase 4)
Intraabdominal Infections (Phase 3)
Keratitis (Phase 3)
Kidney Calculi (Phase 4)
Leukemia (Phase 1/Phase 2)
Leukemia, Lymphocytic, Chronic, B-Cell (Phase 2)
Leukemia, Myeloid, Acute (Phase 1/Phase 2)
Liver Abscess (Phase 3)
Liver Cirrhosis (Phase 4)
Liver Cirrhosis, Alcoholic (Early Phase 1)
Lung Diseases (Phase 4)
Lymph Nodes (Phase 3)
Lymphoma (Phase 3)
Meningitis, Meningococcal (Phase 4)
Metabolic Detoxication, Phase I (Phase 1)
Microbiota (Phase 2)
Middle Ear Ventilation (Phase 3)
Moxifloxacin (Phase 2)
Multiple Myeloma (Phase 3)
Neoplasms (Phase 4)
Nephrolithiasis (Phase 4)
Neutropenia (Phase 4)
Non-Smokers (Phase 1)
Osteomyelitis (Phase 2)
Otitis (Phase 2)
Otitis Externa (Phase 3)
Otitis Media (Phase 4)
Otitis Media with Effusion (Phase 4)
Otorhinolaryngologic Diseases (Phase 2)
Pain, Postoperative (Phase 2/Phase 3)
Pancreatic Diseases (Phase 4)
Pancreatic Neoplasms (Phase 4)
Periapical Abscess (Phase 4)
Peritonitis (Phase 4)
Pharmacokinetics (Phase 1)
Plague (Phase 3)
Pneumonia (Phase 3)
Pneumonia, Ventilator-Associated (Phase 3)
Postoperative Complications (Phase 4)
Pouchitis (Phase 4)
Pregnancy (Phase 4)
Prostatic Hyperplasia (Phase 4)
Prostatic Neoplasms (Phase 4)
Prostatic Neoplasms, Castration-Resistant (Phase 1/Phase 2)
Prostatitis (Phase 2)
Prosthesis-Related Infections (Phase 2)
Pseudomonas aeruginosa (Phase 4)
Pseudomonas Infections (Phase 4)
Pulmonary Disease, Chronic Obstructive (Phase 4)
Purpura (Phase 1)
Pyelonephritis (Phase 4)
Rectal Fistula (Phase 3)
Rectal Neoplasms (Phase 2)
Regeneration (Phase 1)
Respiratory System (Phase 1)
Respiratory Tract Infections (Phase 4)
Rhinoscleroma (Phase 1)
Salivary Gland Diseases (Phase 3)
Sepsis (Phase 3)
Shock, Septic (Phase 3)
Surgical Wound Infection (Phase 4)
Swimming (Phase 3)
Systemic Inflammatory Response Syndrome (Phase 2)
Tooth (Phase 2)
Traumatology (Phase 2)
Tympanic Membrane (Phase 1)
Ureteral Calculi (Phase 4)
Ureteral Diseases (Phase 4)
Urinary Bladder Neoplasms (Phase 3)
Urinary Bladder, Neurogenic (Phase 2)
Urinary Bladder, Overactive (Phase 4)
Urolithiasis (Phase 3)
Ventilators, Mechanical (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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