fludrocortisone (florinef) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Fludrocortisone, sold under the brand name Florinef, among others, is a corticosteroid used to treat adrenogenital syndrome, postural hypotension, and adrenal insufficiency. In adrenal insufficiency, it is generally taken together with hydrocortisone. Fludrocortisone is taken by mouth and is most commonly used in its acetate form.   Wikipedia

Chemistry

  • SMILES: C[C@]12C[C@H](O)[C@@]3(F)[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@]2(O)C(=O)COC(=O)CCC(O)=O
  • InChIKey: RRDDXLOWDKTRPZ-WRCNZEDTSA-N
  • Mol. Mass: 480.5231
  • ALogP: 2.44
  • ChEMBL Molecules:
    fludrocortisone acetate  
    fludrocortisone  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: Yes

Drug Pricing (per unit)

Australia

$0.1120

United States

$0.3378 - $0.5105
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Alternative names

9alpha-fluorocortisol | 9 alpha-fluorocortisol acetate | alflorone acetate | astonin | cortineff | florinef | florinef acetate | fludrocortison | fludrocortisona | fludrocortisone | fludrocortisone 21-acetate | fludrocortisone acetate | fludrocortisonum | fludrocortone | fluohydrocortisone | fluorhydrocortisone acetate | fluorocortisol acetate | fluorohydrocortisone acetate | panotile

Organizations (56)

Research & Development (50)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (6)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (24)

Approved Indications (2)


 

Addison Disease

Adrenogenital Syndrome

Experimental Indications - Clinical Trial Phases 1-4 (22)


 

Adrenal Hyperplasia, Congenital (Phase 2)

Angiotensin I (Phase 1/Phase 2)

COVID-19 (Phase 3)

Critical Illness (Phase 2)

Cyclosteroids (Phase 3)

Deficiency Diseases (Phase 2)

Depression (Phase 1)

Healthy Volunteers (Phase 2)

Hypertension (Phase 4)

Hypotension (Phase 4)

Hypotension, Orthostatic (Phase 1)

Melanoma (Phase 2)

Multiple System Atrophy (Phase 1)

Ovarian Hyperstimulation Syndrome (Phase 2)

Parkinson Disease (Phase 2)

Pharmacokinetics (Phase 1)

Prostatic Neoplasms (Phase 3)

Prostatic Neoplasms, Castration-Resistant (Phase 3)

Severe Acute Respiratory Syndrome (Phase 3)

Shock, Cardiogenic (Phase 3)

Shock, Septic (Phase 3)

Syncope, Vasovagal (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 35
  • # of Trial Organizations: 50

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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