Active Ingredient History

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Fexofenadine is a second-generation, long lasting H1-receptor antagonist (antihistamine) which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, such as the swelling of tissues. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals which produce the effects that we associate with allergy. Fexofenadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of cells by histamine. Unlike most other antihistamines, Fexofenadine does not enter the brain from the blood and, therefore, does not cause drowsiness. Fexofenadine lacks the cardiotoxic potential of terfenadine, since it does not block the potassium channel involved in repolarization of cardiac cells. Fexofenadine is sold under the trade name Allegra among others. ALLEGRA is indicated for the relief of symptoms associated with seasonal allergic rhinitis in adults and children 2 years of age and older.   NCATS

  • SMILES: CC(C)(C(=O)O)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4
  • InChIKey: RWTNPBWLLIMQHL-UHFFFAOYSA-N
  • Mol. Mass: 501.67
  • ALogP: 5.51
  • ChEMBL Molecules:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Over the Counter
  • Delivery Methods: Oral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.1775 - $0.3536

Australia

$0.4339 - $0.9358
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

( fexofenadine (allegra), pseudoephedrine (Benylin) - other names: allegra-d 24 hour allergy and congestion, fexofenadine hcl; pseudoephedrine hcl )
4-(1-hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acid | allegra | allegra allergy | allegra hives | alpha-(4-(1-carboxy-1-methylethyl)phenyl)-4-hydroxydiphenylmethyl-1-piperidinebutanol | aventis behring brand of fexofenadine hydrochloride | aventis brand of fexofenadine hydrochloride | aventis pharma brand of fexofenadine hydrochloride | carboxyterfenadine | fexofenadine | fexofenadine hcl | fexofenadine hydrochloride | fexofenadine hydrochloride allergy | fexofenadine hydrochloride hives | hoechst brand of fexofenadine hydrochloride | mdl 16455 | mdl 16.455 | mdl-16455 | mdl 16,455a | mdl-16455a | telfast | telfast 120 | telfast 180 | telfast 30 | terfenadine acid metabolite | terfenadine carboxylate | terfenadine-cooh

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