ergonovine (Ergotrate) Report issue

Small molecule Experimental
AACT ChEMBL DrugBank Drug Central KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Ergonovine (also known as ergometrine) is the active water soluble component of ergot of rye. Ergonovine is being used as a maleate salt to prevent or treate postpartum haemorrhage and postabortion haemorrhage. Ergonovine stimulates alpha-adrenergic and serotonin receptors, thus activating contractions of uterine and vascular smooth muscle. Ergonovine may have depressant effect on CNS system as it binds to dopamine receptors.   NCATS

Chemistry

  • SMILES: C[C@@H](CO)NC(=O)[C@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34
  • InChIKey: WVVSZNPYNCNODU-XTQGRXLLSA-N
  • Mol. Mass: 325.41
  • ALogP: 1.53
  • ChEMBL Molecules:
    ergonovine  
    ergonovine maleate  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No

Alternative names

(6ar,9r)-7-methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid ((s)-2-hydroxy-1-methyl-ethyl)-amide | [8β(s)]-9,10-didehydro-n-(2-hydroxy-1-methylethyl)-6-methylergoline-8-carboxamide | 9,10-didehydro-n-(2-hydroxy-1-methylethyl)-6-methylergoline-8β(s)-carboxamide | 9,10-didehydro-n-(α-(hydroxymethyl)ethyl)-6-methylergoline-8-β-carboxamide | d-lysergic acid 1-hydroxymethylethylamide | d-lysergic acid-l-propanolamide | ergobasine | ergometrin | ergometrina | ergometrine | ergométrine | ergometrine maleate | ergometrinum | ergonovine | ergonovine maleate | ergostetrine | ergotocine | ergotrate | ergotrate maleate | margonovine | n-(2-hydroxy-1-methylethyl)-d-(+)-lysergamide | n-(α-(hydroxymethyl)ethyl)-d-lysergamide

Organizations (14)

Research & Development (14)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (6)

Approved Indications (2)


 

Postoperative Hemorrhage

Postpartum Hemorrhage

Experimental Indications - Clinical Trial Phases 1-4 (5)


 

Blood Loss, Surgical (Phase 4)

Bronchiectasis (Phase 4)

Cough (Phase 3)

Hemorrhage (Phase 3)

Postpartum Hemorrhage (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 11
  • # of Trial Organizations: 14

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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