Active Ingredient History
Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa concentrations are reached as compared to the administration of levodopa and a decarboxylase inhibitor. The mechanism of action of entacapone is believed to be through its ability to inhibit COMT in peripheral tissues, altering the plasma pharmacokinetics of levodopa. When entacapone is given in conjunction with levodopa and an aromatic amino acid decarboxylase inhibitor, such as carbidopa, plasma levels of levodopa are greater and more sustained than after administration of levodopa and an aromatic amino acid decarboxylase inhibitor alone. It is believed that at a given frequency of levodopa administration, these more sustained plasma levels of levodopa result in more constant dopaminergic stimulation in the brain, leading to a greater reduction in the manifestations of parkinsonian syndrome. Entacapone is used as an adjunct to levodopa / carbidopa in the symptomatic treatment of patients with idiopathic Parkinson's Disease who experience the signs and symptoms of end-of-dose "wearing-off". NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Autonomic Nervous System Diseases (Phase 1/Phase 2)
Cocaine-Related Disorders (Phase 2/Phase 3)
Healthy Volunteers (Phase 1)
Intestinal Neoplasms (Early Phase 1)
Lewy Body Disease (Phase 1)
Methamphetamine (Early Phase 1)
Multiple System Atrophy (Phase 1/Phase 2)
Obesity (Phase 1/Phase 2)
Orthostatic Intolerance (Phase 1/Phase 2)
Pharmacokinetics (Phase 1)
Pure Autonomic Failure (Phase 1)
Tachycardia (Phase 1/Phase 2)
Trial | Phase | Start Date | Organizations | Indications |
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