doxylamine Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

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Doxylamine is an antihistamine commonly used as a sleep aid. This drug is also used to relieve symptoms of hay fever (allergic rhinitis), hives (rash or itching), and other allergic reactions. Doxylamine is a member of the ethanolamine class of antihistamines and has anti-allergy power far superior to virtually every other antihistamine on the market, with the exception of diphenhydramine (Benadryl). It is also the most powerful over-the-counter sedative available in the United States, and more sedating than many prescription hypnotics. In a study, it was found to be superior to even the barbiturate, phenobarbital for use as a sedative. Doxylamine is also a potent anticholinergic. Like other antihistamines, doxylamine acts by competitively inhibiting histamine at H1 receptors. It also has substantial sedative and anticholinergic effects. Used alone as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief drug. Also used in combination with Vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women.   NCATS

Chemistry

More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Over the Counter
  • Delivery Methods: Oral
  • Pro Drug: No

Drug Pricing (per unit)

United States

$0.1159 - $0.2325
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

( doxylamine, pyridoxine - other names: bonjesta, diclegis )

Alternative names

2-(alpha-(2-(dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine | 2-dimethylaminoethoxyphenylmethyl-2-picoline | decapryn | dossilamina | doxilamina | doxilminio | doxylamine | (+/-)-doxylamine | doxylamine succinate | doxylaminum | doxy-sleep-aid | n,n-dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanamine | phenyl-2-pyridylmethyl-beta-n,n-dimethylaminoethyl ether | unisom

Organizations (34)

Research & Development (19)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (16)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (8)

Approved Indications (2)


 

Rhinitis, Allergic (approved 1978)

Sleep Initiation and Maintenance Disorders (approved 1978)

Experimental Indications - Clinical Trial Phases 1-4 (7)


 

Airway Management (Phase 3)

Analgesics, Opioid (Phase 4)

Biological Availability (Phase 1)

Plague (Phase 2)

Pregnancy Complications (Phase 3)

Respiratory Tract Infections (Phase 1)

Rhinitis, Allergic (Phase 1)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 8
  • # of Trial Organizations: 19

Trials by Phase

Trial Phase Start Date Organizations Indications

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