dovitinib Report issue

Small molecule Experimental
AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

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Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown to be associated with Pfeiffer syndrome, and clonal eosinophilias.   Wikipedia

Chemistry

  • SMILES: CN1CCN(CC1)c2ccc3nc([nH]c3c2)C4=C(N)c5c(F)cccc5NC4=O
  • InChIKey: PIQCTGMSNWUMAF-UHFFFAOYSA-N
  • Mol. Mass: 392.44
  • ALogP: 2.54
  • ChEMBL Molecules:
    dovitinib  
    dovitinib lactate  
More Chemistry

Pharmacology

Alternative names

4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl)quinolin-2(1h)-one | chir258 | chir 258 | chir-258 | dovitinib | dovitinib lactate | gfki-258 | nvp-tki258 | tki258 | tki 258 | tki-258

Organizations (37)

Research & Development (37)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (39)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (39)


 

Adenocarcinoma, Scirrhous (Phase 2)

Adrenocortical Carcinoma (Phase 2)

Brain Neoplasms (Phase 2)

Breast Neoplasms (Phase 2)

Carcinoma, Adenoid Cystic (Phase 2)

Carcinoma, Hepatocellular (Phase 2)

Carcinoma, Islet Cell (Phase 2)

Carcinoma, Non-Small-Cell Lung (Phase 2)

Carcinoma, Renal Cell (Phase 3)

Carcinoma, Transitional Cell (Phase 2)

Colorectal Neoplasms (Phase 2)

Endometrial Neoplasms (Phase 2)

Gastrinoma (Phase 2)

Gastrointestinal Stromal Tumors (Phase 2)

Glioblastoma (Phase 2)

Glioma (Phase 2)

Gliosarcoma (Phase 2)

Glucagonoma (Phase 2)

Insulinoma (Phase 2)

Leukemia, Myeloid, Acute (Phase 1)

Linitis Plastica (Phase 2)

Liver Diseases (Phase 1)

Melanoma (Phase 1/Phase 2)

Mesothelioma (Phase 2)

Multiple Myeloma (Phase 2)

Neoplasm Metastasis (Phase 2)

Neoplasms (Phase 2/Phase 3)

Neoplasms by Site (Phase 2)

Pancreatic Neoplasms (Phase 2)

Pheochromocytoma (Phase 2)

Prostatic Neoplasms (Phase 2)

Salivary Gland Neoplasms (Phase 2)

Somatostatinoma (Phase 2)

Stomach Diseases (Phase 2)

Stomach Neoplasms (Phase 2)

Thyroid Neoplasms (Phase 2)

Urinary Bladder Neoplasms (Phase 2)

Vascular Endothelial Growth Factor A (Phase 2)

von Hippel-Lindau Disease (Phase 2)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 57
  • # of Trial Organizations: 37

Trials by Phase

Trial Phase Start Date Organizations Indications

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