Active Ingredient History
Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R. It has been approved for the treatment of insomnia. The mechanism by which suvorexant exerts its therapeutic effect in insomnia is presumed to be through antagonism of orexin receptors. The orexin neuropeptide signaling system is a central promoter of wakefulness. Blocking the binding of wake-promoting neuropeptides orexin A and orexin B to receptors OX1R and OX2R is thought to suppress wake drive. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Alcohol-Induced Disorders (Phase 2)
Alcoholism (Phase 2)
Alzheimer Disease (Phase 3)
Analgesics, Opioid (Phase 2)
Anxiety (Phase 2)
Autism Spectrum Disorder (Phase 2)
Autistic Disorder (Phase 2)
Bipolar Disorder (Phase 4)
Breast Neoplasms (Phase 4)
Cocaine-Related Disorders (Phase 2)
Cognitive Aging (Phase 2)
Cortisone (Phase 2/Phase 3)
Craving (Phase 2/Phase 3)
Delirium (Phase 3)
Depression (Phase 4)
Depressive Disorder (Phase 4)
Depressive Disorder, Major (Phase 4)
Diabetes Mellitus (Phase 4)
Diabetes Mellitus, Type 2 (Phase 4)
Drugs, Investigational (Phase 2)
Fatigue (Phase 4)
Fibromyalgia (Phase 4)
Healthy Volunteers (Phase 1)
Hepatic Insufficiency (Phase 1)
Hypertension (Phase 4)
Inflammation (Phase 4)
Menopause (Phase 4)
Methamphetamine (Phase 2)
Multiple Sclerosis (Phase 4)
Opioid-Related Disorders (Phase 2)
Panic Disorder (Early Phase 1)
Performance-Enhancing Substances (Early Phase 1)
Placebos (Phase 2)
Postoperative Complications (Phase 4)
Restless Legs Syndrome (Phase 4)
Sleep (Phase 2)
Sleep Apnea Syndromes (Phase 1)
Sleep Deprivation (Phase 4)
Sleep Disorders, Circadian Rhythm (Phase 4)
Sleep Disorders, Intrinsic (Phase 2/Phase 3)
Sleep Wake Disorders (Phase 4)
Smoking Cessation (Phase 2)
Stress Disorders, Post-Traumatic (Phase 4)
Substance Abuse, Oral (Phase 1)
Substance-Related Disorders (Phase 2)
Therapeutics (Phase 4)
Tobacco Use Disorder (Phase 1)
Trial | Phase | Start Date | Organizations | Indications |
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