Active Ingredient History
Alpha-1 antitrypsin or α1-antitrypsin is a protein belonging to the serpin superfamily. It is encoded in humans by the SERPINA1 gene. A protease inhibitor, it is also known as alpha1–proteinase inhibitor (A1PI) or alpha1-antiproteinase (A1AP) because it inhibits various proteases. In older biomedical literature it was sometimes called serum trypsin inhibitor, because its capability as a trypsin inhibitor was a salient feature of its early study. As a type of enzyme inhibitor, it protects tissues from enzymes of inflammatory cells, especially neutrophil elastase, and has a reference range in blood of 0.9–2.3 g/L, but the concentration can rise manyfold upon acute inflammation. Wikipedia
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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alpha 1-Antitrypsin Deficiency (approved 1987)
alpha 1-Antitrypsin Deficiency (Phase 4)
Bronchiectasis (Phase 4)
Bronchiolitis (Phase 2)
Bronchoscopy (Phase 4)
Coronavirus (Early Phase 1)
COVID-19 (Phase 3)
Cystic Fibrosis (Phase 2)
Deficiency Diseases (Phase 4)
Diabetes Mellitus (Phase 4)
Diabetes Mellitus, Type 1 (Phase 2)
Emphysema (Phase 4)
Eosinophilic Esophagitis (Phase 2)
General Surgery (Phase 1/Phase 2)
Graft vs Host Disease (Phase 3)
Healthy Volunteers (Phase 4)
Hemophilia A (Phase 2)
Hemophilia B (Phase 2)
HIV Infections (Phase 2/Phase 3)
Kidney Transplantation (Phase 2)
Lung Transplantation (Phase 2)
Myocardial Infarction (Phase 1/Phase 2)
Neuromyelitis Optica (Phase 1)
Pancreas (Phase 2)
Pancreatitis, Chronic (Phase 1/Phase 2)
Pneumonia, Viral (Phase 3)
Prostatic Hyperplasia (Phase 4)
Pulmonary Disease, Chronic Obstructive (Phase 4)
Trial | Phase | Start Date | Organizations | Indications |
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